芍药汤加减联合FOLFOX6方案、常规治疗对湿热蕴结型结直肠癌术后辅助化疗患者的临床疗效  

Clinical effects of Modified Shaoyao Decoction combined with FOLFOX6 regimen and conventional treatment on patients demanding postoperative adjuvant chemotherapy for colorectal cancer due to Damp-heat Accumulation

作　　者：赖曼 李娟[1] 李瑶 李卓虹[1] LAI Man;LI Juan;LI Yao;LI Zhuo-hong(The Second Department of Oncology,The Hospital Affiliated to Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China;Department of Neurology,Chengdu Shangjin Nanfu Hospital,Chengdu 611730,China)

机构地区：[1]成都中医药大学附属医院肿瘤二科,四川成都610072 [2]成都上锦南府医院神经内科,四川成都611730

出　　处：《中成药》2022年第9期2834-2838,共5页Chinese Traditional Patent Medicine

基　　金：国家中医药管理局课题(2019XZZX-ZL006)。

摘　　要：目的探讨芍药汤加减联合FOLFOX6方案、常规治疗对湿热蕴结型结直肠癌术后辅助化疗患者的临床疗效。方法146例患者随机分为对照组和观察组,每组73例,对照组给予FOLFOX6方案、常规治疗(抑酸、止吐等),观察组在对照组基础上加用芍药汤加减。检测中医证候疗效、KPS评分、T淋巴细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、NK细胞)、TNF-α、IL-4、CXCR4、毒副作用变化。结果观察组总有效率高于对照组(P<0.05),恶心呕吐、腹泻、肝功能损害、皮肤损害发生率及严重程度更低(P<0.05)。治疗后,观察组KPS评分、CD4^(+)、NK细胞、CD4^(+)/CD8^(+)、IL-4高于对照组(P<0.05),TNF-α、CXCR4更低(P<0.05)。2组骨髓抑制、神经毒性发生率及严重程度比较,差异无统计学意义(P>0.05)。结论芍药汤加减联合FOLFOX6方案、常规治疗可增强湿热蕴结型结直肠癌术后辅助化疗患者机体免疫功能,减轻炎症反应和毒副作用,改善临床症状。AIM To explore the clinical effects of Modified Shaoyao Decoction combined with FOLFOX6 regimen and conventional treatment on patients demanding postoperative adjuvant chemotherapy for colorectal cancer due to Damp-heat Accumulation.METHODS One hundred and forty-six patients were randomly assigned into control group(73 cases)for intervention of FOLFOX6 regimen and conventional treatment(acid suppression,anti-emesis,etc.),and observation group(73 cases)for intervention of Modified Shaoyao Decoction,FOLFOX6 regimen and conventional treatment.The changes in TCM syndrome efficacy,KPS score,T lymphocyte subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+),NK cells),TNF-α,IL-4,CXCR4 and toxicity and side effects were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05),along with lower incidence and severities of nausea and vomiting,diarrhea,liver function damage and skin damage(P<0.05).After the treatment,the observation group displayed higher KPS score,CD4^(+),NK cells,CD4^(+)/CD8^(+)and IL-4 than the control group(P<0.05),along with lower TNF-αand CXCR4(P<0.05).No significant differences in incidence and severities of myelosuppression and neurotoxicity were found between the two groups(P>0.05).CONCLUSION For the patients demanding postoperative adjuvant chemotherapy for colorectal cancer due to Damp-heat Accumulation,Modified Shaoyao Decoction combined with FOLFOX6 regimen and conventional treatment can enhance body immune functions,relieve inflammatory responses and toxicity and side effects,and improve clinical symptoms.

关 键 词：芍药汤 FOLFOX6方案 常规治疗 结直肠癌 术后辅助化疗 湿热蕴结 

分 类 号：R287[医药卫生—中药学]