冬虫夏草内生菌 Fusarium solani 化学成分研究  

Chemical constituents from endophytic fungus Fusarium solani of Cordyceps sinensis

作　　者：旷歧轩 李青洲 雷力荣 郭大乐[1] 邓赟[1] KUANG Qi-xuan;LI Qing-zhou;LEI Li-rong;GUO Da-le;DENG Yun*(State Key Laboratory of Southwestern Chinese Medicine Resource,Ministry of Education Key Laboratory for Standardization of Chinese Herbal Medicine,College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学药学院,中药材标准化教育部重点实验室,西南特色中药资源国家重点实验室,四川成都611137

出　　处：《中成药》2022年第9期2866-2873,共8页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金面上项目(81973460);四川省科技厅应用基础研究项目(2018JY0186);四川省教育厅科研项目(18ZA0191)。

摘　　要：目的研究冬虫夏草内生菌Fusarium solani化学成分。方法Fusarium solani乙酸乙酯提取物采用硅胶、Sephadex LH-20、制备HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离鉴定出25个化合物。结论化合物1~17、19~24为首次从该真菌的次生代谢产物中发现。AIM To study the chemical constituents from endophytic fungus Fusarium solani of Cordyceps sinensis(Berk.)Sacc.METHODS The ethyl acetate extract from Fusarium solani was isolated and purified by silica,Sephadex LH-20 and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Twenty-five compounds were isolated and identified.CONCLUSION Compounds 1-17,19-24 are found from the secondary metabolites of this fungi for the first time.

关 键 词：冬虫夏草 内生菌 Fusarium solani 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]