血清血管生成素样蛋白8、白细胞介素-23水平与缺血性卒中患者颈动脉斑块易损风险的关系  

Relationship between serum angiopoietin-like protein 8,interleukin-23 levels and the risk of carotid plaque vulnerability in patients with ischemic stroke

作　　者：安然 杨璐 艾志兵[1] AN Ran;YANG Lu;AI Zhibing(Department of Neurology,Shiyan Taihe Hospital,Hubei Province,Shiyan 442000,China)

机构地区：[1]湖北省十堰市太和医院神经内科,湖北十堰442000

出　　处：《中国医药导报》2022年第26期58-61,74,共5页China Medical Herald

基　　金：湖北省卫生健康委科研项目(WJ2019Q014)。

摘　　要：目的探讨血清血管生成素样蛋白8(ANGPTL8)、白细胞介素-23(IL-23)水平与缺血性卒中(IS)患者颈动脉斑块易损风险的关系。方法选取2020年1月至2021年9月湖北省十堰市太和医院收治的197例IS患者,根据颈动脉血管超声检查结果将197例IS患者分为易损组(112例)、稳定组(46例)、无斑块组(39例)。分析IS患者颈动脉斑块易损风险的影响因素,受试者工作特征(ROC)曲线分析血清ANGPTL8、IL-23水平对IS患者颈动脉斑块易损风险的预测价值。结果易损组血清超敏C反应蛋白(hs-CRP)、ANGPTL8、IL-23水平高于稳定组、无斑块组,稳定组血清ANGPTL8、IL-23水平高于无斑块组(P<0.05)。易损组、稳定组低密度脂蛋白胆固醇(LDL-C)水平高于无斑块组,高密度脂蛋白胆固醇水平低于无斑块组(P<0.05)。LDL-C、hs-CRP、ANGPTL8、IL-23为IS患者颈动脉斑块易损风险的独立危险因素(OR>1,P<0.05)。ANGPTL8、IL-23联合预测IS患者颈动脉斑块易损风险的曲线下面积高于ANGPTL8、IL-23单独预测(P<0.05)。结论血清ANGPTL8、IL-23水平为IS患者颈动脉斑块易损风险的独立危险因素,可作为颈动脉斑块易损风险的预测指标。Objective To investigate the relationship between serum angiopoietin-like protein 8(ANGPTL8)and interleukin-23(IL-23)levels and the risk of carotid plaque vulnerability in patients with ischemic stroke(IS).Methods A total of 197 patients with IS who were admitted to Shiyan Taihe Hospital,Hubei Province from January 2020 to September 2021 were selected.They were divided into vulnerable group(112 cases),stable group(46 cases),non-plaque(39 cases)according to the result of carotid ultrasound examination.The influencing factors of carotid plaque vulnerability risk in patients with IS were analyzed,and the receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum ANGPTL8 and IL-23 levels on carotid plaque vulnerability risk in patients with IS.Results The serum levels of hypersensitivity C-reactive protein(hs-CRP),ANGPTL8,and IL-23 in vulnerable group were higher than those in stable group and non-plaque group,and the serum levels of ANGPTL8 and IL-23 in stable group were higher than those in non-plaque group(P<0.05).The levels of low density lipoprotein cholesterol(LDL-C)in vulnerable group and stable group were higher than those in non-plaque group,and the levels of high density lipoprotein cholesterol were lower than those in non-plaque group(P<0.05).LDL-C,hs-CRP,ANGPTL8,and IL-23 were independent risk factors for carotid plaque vulnerability risk in IS patients(OR>1,P<0.05).The area under the curve of ANGPTL8 and IL-23 combined to predict the carotid plaque vulnerability risk in patients with IS was higher than that of ANGPTL8 and IL-23 alone(P<0.05).Conclusion Serum ANGPTL8 and IL-23 levels are independent risk factors for carotid plaque vulnerability risk in IS patients,and can be used as predictors of carotid plaque vulnerability risk.

关 键 词：缺血性卒中 颈动脉斑块 斑块易损性 血管生成素样蛋白8 白细胞介素-23 

分 类 号：R543[医药卫生—心血管疾病]