基于熵权法的正交试验优选小儿宝泰康颗粒醇提工艺  

Optimization of Alcohol Extraction Process of Xiao'er Baotaikang Granules by the Orthogonal Test Based on Entropy Weight Method

作　　者：张清文[1] 汪正宇 ZHANG Qingwen;WANG Zhengyu(Department of Pharmacy,Wanbei Coal-Electricity Corporation General Hospital,Suzhou,Anhui,China 234000;Suzhou Food and Drug Inspection and Testing Center,Suzhou,Anhui,China 234000)

机构地区：[1]皖北煤电集团总医院药剂科,安徽宿州234000 [2]安徽省宿州市食品药品检验检测中心,安徽宿州234000

出　　处：《中国药业》2022年第18期62-65,共4页China Pharmaceuticals

摘　　要：目的优选小儿宝泰康颗粒醇提工艺。方法采用基于熵权法的正交试验,以料液比、甲醇体积分数、提取时间为考察因素,绿原酸、连翘酯苷A、连翘苷、柴胡皂苷d、甘草酸铵含量为评价指标,计算各指标的信息熵及权重系数,并进行综合评分,对小儿宝泰康颗粒有效成分醇提工艺进行优选,并验证。结果料液比和提取时间对综合评分有显著影响(P<0.05)。小儿宝泰康颗粒有效成分最优醇提工艺为,50倍量50%甲醇提取90 min。验证试验中,上述5种成分含量的RSD均小于0.40%(n=3)。结论基于熵权法优选的小儿宝泰康颗粒醇提工艺稳定可行。Objective To optimize the alcohol extraction process of Xiao'er Baotaikang Granules.Methods The material-liquid ratio,volume fraction of methanol and extraction time were taken as the factors,and the contents of chlorogenic acid,forsythoside A,forsythin,saikosaponin D and ammonium glycyrrhizinate were taken as the evaluation indexes,the information entropy and weight coefficient of each index were calculated and the comprehensive score was carried out,the alcohol extraction process of Xiao'er Baotaikang Granules was optimized and verified by the orthogonal test based on entropy weight method.Results The material-liquid ratio and extraction time had significant effects on the comprehensive score(P<0.05).The optimal alcohol extraction process of Xiao'er Baotaikang Granules was as follows:50 times of 50% methanol extraction for 90 min.In the validation test,the RSD of the above five components was less than 0.40%(n=3).Conclusion The alcohol extraction process of Xiao'er Baotaikang Granules based on the entropy weight method is stable and feasible.

关 键 词：小儿宝泰康颗粒 有效成分 正交试验 多指标 熵权法 权重分析 

分 类 号：R943[医药卫生—药剂学] R932[医药卫生—药学]