不同剂量免疫球蛋白联合阿司匹林对川崎病患儿临床疗效、炎性反应及免疫功能的影响  

Impact of Different Doses of Immunoglobulin Combined with Aspirin on Clinical Efficacy,Inflammatory Response and Immune Function in Children with Kawasaki Disease

作　　者：杨峻[1] 方昕[1] 廖伟强[1] 解琼[1] YANG Jun;FANG Xin;LIAO Weiqiang;XIE Qiong(Dongguan Houjie Hospital,Dongguan 523945,China)

机构地区：[1]东莞市厚街医院,广东东莞523945

出　　处：《临床医学工程》2022年第9期1257-1258,共2页Clinical Medicine & Engineering

摘　　要：目的探讨不同剂量免疫球蛋白联合阿司匹林治疗对川崎病患儿临床疗效、炎性反应及免疫功能的影响。方法将我院收治的70例川崎病患儿随机分为A组和B组各35例。A组采用大剂量免疫球蛋白联合阿司匹林治疗,B组采用常规剂量免疫球蛋白联合阿司匹林治疗。比较两组患儿的临床疗效、炎性指标(CRP)及免疫功能指标(CD4^(+)T细胞、CD8^(+)T细胞、CD4^(+)/CD8^(+)T)。结果A组治疗总有效率为94.29%,明显高于B组的71.43%(P<0.05)。治疗后,A组的CRP、CD4^(+)T细胞、CD4^(+)/CD8^(+)T水平均低于B组,CD8^(+)T细胞水平高于B组(P<0.05)。结论大剂量免疫球蛋白联合阿司匹林治疗川崎病效果更为显著,可明显减轻患儿的炎性反应,改善其免疫功能。Objective To explore the clinical effect of different doses of immunoglobulin combined with aspirin on clinical efficacy,inflammatory response and immune function in children with Kawasaki disease.Methods 70 children with Kawasaki disease admitted to our hospital were randomly divided into group A and group B euqally.Group A was treated with high-dose immunoglobulin combined with aspirin,and group B was treated with routine-dose immunoglobulin combined with aspirin.The clinical efficacy,inflammatory indicators(CRP)and immune function indicators(CD4^(+)T cells,CD8^(+)T cells,CD4^(+)/CD8^(+)T)were compared between the two groups.Results The total effective rate of treatment in group A was 94.29%,significantly higher than 71.43%in group B(P<0.05).After treatment,the levels of CRP,CD4^(+)T cells and CD4^(+)/CD8^(+)T in group A were lower than those in group B,and the level of CD8^(+)T cells was higher than that in group B(P<0.05).Conclusions High-dose immunoglobulin combined with aspirin in the treatment of Kawasaki disease has significant effect,and can significantly reduce the inflammatory response and improve the immune function of children.

关 键 词：免疫球蛋白 阿司匹林 川崎病 临床疗效 炎性反应 免疫功能 

分 类 号：R725.4[医药卫生—儿科]