甲状旁腺激素及甲状旁腺激素相关肽对正畸过程中组织改建的影响  

Effect of parathyroid hormone and parathyroid hormone-related peptides on tissue remodeling during orthodontics

作　　者：孙小桐 程艺 毕蓝 王慧达 张荣和[1] Sun Xiaotong;Cheng Yi;Bi Lan;Wang Huida(Department of Orthodontics,Affiliated Hospital of Binzhou Medical University,Binzhou 256600,Shandong Province,China)

机构地区：[1]滨州医学院附属医院口腔正畸科,山东省滨州市256600

出　　处：《中国组织工程研究》2023年第14期2234-2241,共8页Chinese Journal of Tissue Engineering Research

摘　　要：背景:甲状旁腺激素及甲状旁腺素相关肽是体内矿物质代谢合成的重要调节因子,作用机制复杂,通过调整作用方式可以刺激骨的合成代谢,也可以刺激骨的分解代谢,在骨骼及牙齿硬组织形成中发挥重要作用,是口腔领域的热门研究方向。目的:结合国内外文献对甲状旁腺激素和甲状旁腺素相关肽在正畸过程中对组织改建的影响及其相关作用研究进展作一综述,以期为它们用于正畸临床治疗的进一步研究提供参考。方法:第一作者检索近20年Pub Med数据库、中国知网、维普和万方数据库收录的相关文章。英文检索词为“PTH,PTHr P,orthodontics,TMJ,OTM,root resorption,periodontal”,中文检索词为“甲状旁腺激素,甲状旁腺激素相关肽,正畸牙移动,牙根吸收,正畸,颞下颌关节,牙周”。共选取57篇文献进行综述。结果与结论:甲状旁腺激素及甲状旁腺素相关肽在骨、软骨、牙体组织改建方面均具有良好的调节作用,可以在口腔正畸治疗相关方面获得较好效果,包括加速牙移动、修复牙根吸收、维持正畸疗效的稳定等,但仍需要更多更高质量的动物实验及临床研究证实其具体作用、使用方法及对全身健康的影响。未来甲状旁腺激素类药物及其类似物可作为正畸治疗的辅助手段,在加速正畸治疗的同时,降低并发症风险,获得更好的治疗效果。BACKGROUND:Parathyroid hormone and parathyroid hormone-related peptide are important regulato rs of mineral metabolism and synthesis in the body with co mplex action mechanisms.By adjusting the mode of action,parathyroid hormone and parathyroid hormone-related peptide can stimulate bone anabolism and catabolis m,which play an important role in the formation of bone and dental hard tissues.This is a popular research direction in the field of stomatology.OBJECTIVE:Based on the literature at home and abroad,to make an overall review on the research and progress of parathyroid hormone and parathyroid hormone-related peptide in orthodontic treatment,with the aim of providing refe rences for further research of parathyroid hormone and parathyroid hormone-related peptide in orthodontic treatment.METHODS:The first author retrieved the relevant articles included in PubMed,CNKI,VIP,and Wang Fang databases in the past 20 years.A total of 57 articles were included for review with "PTH,PTHrP,orthodontics,TMJ,OTM,root resorption,periodontal" as English and Chinese search terms,respectively.RESULTS AND CONCLUSION:Parathyroid hormone and parathyroid hormone-related peptide have good regulato ry effects on bone,ca rtilage,and dental tissue reconstruction and achieve good effects in orthodontic treatment,including accele rating tooth movement,repairing root resorption and maintaining the stability of orthodontic effect.Howeve r,more and higher-quality animal experiments and clinical studies are still needed to confirm its specific effects,application methods and effects on general health.In the future,parathyroid hormone drugs and their analogues will assist in orthodontic treatment,which cannot only accelerate orthodontic treatment,but also reduce the risk of complications and obtain better treatment outcomes.

关 键 词：甲状旁腺激素 甲状旁腺激素相关肽 正畸 牙根吸收 颞下颌关节 髁突软骨 牙周 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R783