女性体重指数对夫精人工授精结局的影响  

Influence of female body mass index on the outcome of artificial insemination by husband sperm

作　　者：姜雯雯[1] 朱素芹[1] 李榕珊 陈晓菁[1] JIANG Wenwen;ZHU Suqin;LI Rongshan;CHEN Xiaojing(Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and Pediatrics,Fujian Medical University,Fujian Province,Fuzhou 350001,China)

机构地区：[1]福建省妇幼保健院福建医科大学妇儿临床医学院,福建福州350001

出　　处：《中国当代医药》2022年第26期116-119,共4页China Modern Medicine

基　　金：福建省自然科学基金项目(2021J05080);福建省卫生健康科研人才培养项目(2019-2-9);福建省卫生健康省级专项补助资金(闽财指〔2019〕827号)。

摘　　要：目的探讨辅助生殖夫精人工授精技术对女性患者不同体重指数(BMI)临床结局的影响。方法回顾性分析2018年1月至2020年12月在福建省妇幼保健院生殖医学中心接受夫精人工授精(AIH)的患者夫妇双方的资料,按照女性BMI分为低体重组(BMI<18.5 kg/m^(2))、正常体重组(18.5 kg/m^(2)≤BMI<24 kg/m^(2))、超重体重组(BMI≥24 kg/m^(2))。将三组患者行AIH助孕的基本资料及临床结局进行统计分析。结果三组患者的流产率和早产率比较,差异有统计学意义(P<0.05)。经Bonferroni校正后,超重体重组的流产率和早产率高于正常体重组,差异有统计学意义(P<0.017)。对BMI≥24 kg/m^(2)患者行AIH的促排卵方案进行研究,促排卵周期的妊娠率高于自然周期(15.9%vs.10.0%),差异有统计学意义(P<0.05)。促排卵周期和自然周期的流产率、早产率和足月产率比较,差异均无统计学意义(P>0.05)。结论AIH助孕的超重体重组女性较低体重及正常体重者有更高的妊娠丢失率及早产率,这部分女性行促排卵方案AIH助孕可能有助于改善其妊娠结局。Objective To explore the influence of different body mass index(BMI)of female patients on clinical outcome with assisted reproductive sperm artificial insemination by husband sperm technology.Methods The clinical data of the patients and her husband who received artificial insemination by husband sperm(AIH)in the Reproductive Medicine Center of Fujian Maternal and Child Health Hospital from January 2018 to December 2020 were retrospectively analyzed,and they were divided into the low body weight group(BMI<18.5 kg/m^(2)),the normal body weight group(18.5 kg/m^(2)≤BMI<24 kg/m^(2)),the overweight group(BMI≥24 kg/m^(2))based on their BMI.The basic data and clinical outcomes of AIH assisted pregnancy in the three groups were statistically analyzed.Results There were significant differences in the abortion rate and premature birth rate among the three groups(P<0.05).After Bonferroni's correction,the rate of abortion and premature birth in the overweight group were higher than those of the normal weight group,and the differences were statistically significant(P<0.017).Patients with BMI≥24 kg/m^(2) underwent AIH ovulation induction program,and the pregnancy rate of ovulation induction cycle was higher than that of natural cycle(15.9%vs.10.0%),the difference was statistically significant(P<0.05).There were no significant differences in the abortion rate,premature birth rate and full term birth rate between ovulation induction cycle and natural cycle(P>0.05).Conclusion AIH assisted pregnancies of overweight women have higher pregnancy loss rate and preterm delivery rate than those of low weight and normal weight women.AIH assisted pregnancies may be helpful to improve their pregnancy outcomes.

关 键 词：夫精人工授精 体重指数 超重 临床结局 

分 类 号：R699.7[医药卫生—泌尿科学]