地佐辛超前镇痛在甲状腺手术中的效果观察  

Observation on the effect of dezocine preemptive analgesia in thyroid surgery

作　　者：曾召生 ZENG Zhao-sheng(Department of Anesthesiology,Chaoyang County Central Hospital,Chaoyang 122000,China)

机构地区：[1]辽宁省朝阳县中心医院麻醉科,122000

出　　处：《中国实用医药》2022年第19期139-141,共3页China Practical Medicine

摘　　要：目的探究甲状腺手术患者采用地佐辛超前镇痛的临床效果。方法76例甲状腺手术患者,随机分为对照组与实验组,各38例。两组患者均采用统一的麻醉方案,对照组在切皮前静脉推注生理盐水,实验组在切皮前经静脉推注地佐辛进行超前镇痛。对比两组术后疼痛评分、不良反应发生情况及血浆白细胞介素-6(IL-6)浓度。结果术后2、12、24 h,实验组视觉模拟评分法(VAS)评分分别为(1.61±0.89)、(2.74±0.75)、(2.36±0.58)分,均低于对照组的(6.12±1.73)、(5.08±1.12)、(3.75±0.94)分,差异有统计学意义(P<0.05)。实验组不良反应发生率为18.42%,低于对照组的39.47%,差异有统计学意义(P<0.05)。术后24、48、72 h,实验组血浆IL-6浓度分别为(86.27±9.05)、(73.32±8.36)、(75.21±6.13)pg/ml,均低于对照组的(98.13±8.32)、(92.71±4.83)、(89.27±5.84)pg/ml,差异均有统计学意义(P<0.05)。结论甲状腺手术患者采用地佐辛超前镇痛进行辅助治疗,可以有效减轻患者的疼痛程度,降低机体炎症介质IL-6浓度,预防各类不良反应的出现,可有效提高患者手术效果以及预后水平,值得临床进一步应用与推广。Objective To investigate the clinical effect of dezocine preemptive analgesia in thyroid surgery.Methods A total of 76 patients with thyroid surgery were selected as the research subjects,and they were randomly divided into the control group and the experimental group,with 38 cases in each group.Both groups were treated with a unified anesthesia regimen.The control group received intravenous injection of normal saline before skin incision,and the experimental group received preemptive analgesia by intravenous injection of dezocine before skin incision.The postoperative pain scores,occurrence of adverse reactions and plasma interleukin-6(IL-6)levels were compared between the two groups.Results At 2,12,and 24 h after surgery,the visual analogue scale(VAS)scores of the experimental group were(1.61±0.89),(2.74±0.75),and(2.36±0.58)points,which were lower than(6.12±1.73),(5.08±1.12),and(3.75±0.94)points of the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 18.42%,which was lower than 39.47%in the control group,and the difference was statistically significant(P<0.05).At 24,48,and 72 h after surgery,the plasma IL-6 levels in the experimental group were(86.27±9.05),(73.32±8.36),and(75.21±6.13)pg/ml,which were lower than(98.13±8.32),(92.71±4.83),and(89.27±5.84)pg/ml in the control group,and the differences were statistically significant(P<0.05).Conclusion Dezocine preemptive analgesia for adjuvant therapy in patients with thyroid surgery can effectively reduce the degree of pain of patients,reduce the level of inflammatory mediator IL-6 in the body,prevent the occurrence of various adverse reactions,and effectively improve the surgical effect and prognosis of patients,which is worthy of further clinical application and promotion.

关 键 词：地佐辛 超前镇痛 甲状腺手术 临床效果 

分 类 号：R614[医药卫生—麻醉学]