非布司他片长期治疗高尿酸血症伴痛风患者的安全性和有效性分析  

Analysis of safety and effectiveness of febuxostat tablets in the long-term treatment of patients with hyperuricemia and gout

作　　者：张秀英[1] 崔彦辉 董汉玉 ZHANG Xiu-ying;CUI Yan-hui;DONG Han-yu(Department of Rheumatology and Immunology,Zibo Central Hospital,Zibo 255000,China)

机构地区：[1]淄博市中心医院风湿免疫科,255000 [2]淄博市妇幼保健院内分泌科,255000

出　　处：《中国实用医药》2022年第19期142-145,共4页China Practical Medicine

摘　　要：目的评价高尿酸血症伴痛风患者应用非布司他片长期治疗的价值。方法64例高尿酸血症伴痛风患者,根据治疗方法不同分为观察组与对照组,各32例。对照组患者行常规治疗,观察组患者行非布司他片治疗。比较两组疗效、不良反应发生率、治疗前后的血尿酸水平。结果观察组治疗总有效率为93.75%,高于对照组的71.88%,差异有统计学意义(P<0.05)。观察组不良反应发生率为3.13%,低于对照组的25.00%,差异有统计学意义(P<0.05)。治疗后6周,两组血尿酸水平均较治疗前降低,且观察组血尿酸(321.47±45.69)μmol/L低于对照组的(361.47±61.58)μmol/L,差异有统计学意义(P<0.05)。结论高尿酸血症伴痛风患者应用非布司他片长期治疗,可改善患者血尿酸水平,且不良反应较少,值得临床推广。Objective To evaluate the value of febuxostat tablets in the long-term treatment of patients with hyperuricemia and gout.Methods A total of 64 patients with hyperuricemia and gout were divided into observation group and control group according to different treatment methods,with 32 cases in each group.Patients in the control group were treated with conventional treatment,and patients in the observation group were treated with febuxostat tablets.The efficacy,incidence of adverse reactions,and blood uric acid levels before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.75%,which was higher than 71.88%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 3.13%,which was lower than 25.00%in the control group,and the difference was statistically significant(P<0.05).At 6 weeks after treatment,the levels of blood uric acid in the two groups were decreased compare with those before treatment in this group,and the blood uric acid(321.47±45.69)μmol/L in the observation group was lower than(361.47±61.58)μmol/L in the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of patients with hyperuricemia and gout,long-term treatment of febuxostat tablets can improve the blood uric acid level of the patients with fewer adverse reactions,which is worthy of clinical promotion.

关 键 词：高尿酸血症 痛风 非布司他片 血尿酸 疗效 

分 类 号：R589.7[医药卫生—内分泌]