血必净注射液对腹腔镜围术期患者炎性反应的抑制和器官保护作用  

Effect of Xuebijing injection on inflammatory response and organ protection in perioperative patients under laparoscopy

作　　者：彭一峰 莫晔 周芳 黄谙非 PENG Yifeng;MO Ye;ZHOU Fang;HUANG Anfei(Southern University of Science and Technology Hospital,Guangdong Province,Shenzhen 518000,China;不详)

机构地区：[1]南方科技大学医院,广东省深圳市518000

出　　处：《临床合理用药杂志》2022年第22期23-26,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：深圳市南山区技术研发和创意设计项目分项资金教育(卫生)科技项目(2019076);深圳市南山区技术研发和创意设计项目分项资金教育(卫生)科技项目(2019025)。

摘　　要：目的探讨血必净注射液对腹腔镜手术患者围术期炎性反应抑制和器官功能的保护作用。方法选择2020年3月—2021年3月南方科技大学医院普外科行腹腔镜手术无中转开腹的住院患者60例,采用随机数字表法分为观察组及对照组,各30例。观察组患者术前给予血必净注射液2 ml/kg+生理盐水100 ml,对照组患者术前给予生理盐水200 ml。2组患者均于术前(T_(1))、术毕(T_(2))、术后12 h(T_(3))或术后3 d早上6:00(T_(4))取血,测定患者体温、血清白介素-6(IL-6)、血常规、C反应蛋白(CRP)、肝肾功能、空腹血糖(FBG),比较2组不良反应。结果T_(3)时,观察组体温低于对照组,差异有统计学意义(P<0.01)。T_(2)时,观察组血清IL-6水平低于对照组,差异有统计学意义(P<0.05)。T_(1)、T_(3)时,2组患者白细胞(WBC)、中性粒细胞比例(NE)、肌酐(CRE)、空腹血糖(FBG)组内及组间比较差异无统计学意义(P>0.05);T_(3)时,2组CRP、总胆红素(TBil)、直接胆红素(DB)水平较T_(1)明显升高,尿素(UREA)水平较T_(1)明显降低,差异均有统计学意义(P<0.05),但T_(3)时,2组间CRP、TBil、DB水平比较差异均无统计学意义(P>0.05);T_(3)时,对照组患者丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)均较T_(1)时及观察组T_(3)时明显升高,差异均有统计学意义(P<0.05),但T_(1)、T_(3)时,观察组患者ALT及AST水平比较差异均无统计学意义(P>0.05)。观察组使用血必净注射液后均未出现全身皮疹、呼吸困难、心律失常、过敏性休克等严重不良反应,所有患者术中、术后生命体征均平稳,无血栓栓塞、心律失常等并发症,均未接受二次手术。结论腹腔镜手术中使用血必净注射液可有效减轻围术期的炎性反应,对围术期肝功能有显著的保护作用,有助于患者术后恢复,且安全有效。Objective To investigate the protective effects ofXuebijinginjection on perioperative inflammatory response and organ function in patients undergoing laparoscopic surgery.Methods A total of 60 hospitalized patients without conversion to laparotomy who underwent laparoscopic surgery in general surgery department of Southern University of Science and Technology Hospital from March 2020 to March 2021 were selected,and the patients were divided into observation group and control group by random number table method,with 30 patients in each group.Observation group was givenXuebijing injection 2 ml/kg+normal saline 100 ml before surgery,and control group was given normal saline 200 ml before surgery.Blood samples were taken from 2 groups before operation(T_(1)),after operation(T_(2)),12 h after operation(T_(3))or at 6:00 am(T_(4))on 3 d after operation,The body temperature,serum interleukin-6(IL-6),blood routine,C-reactive protein(CRP),liver and kidney function,fasting blood glucose(FBG)were measured,and adverse reactions were compared between2 groups.Results At T_(3),the body temperature of the observation group was lower than that of the control group,the difference was statistically significant(P<0.01).At T_(2),the serum IL-6 level of observation group was lower than that of control group,the difference was statistically significant(P<0.05).At T_(1)and T_(3),there were no significant differences in white blood cell(WBC),neutrophil ratio(NE),creatinine(CRE)and FBG within and between 2 groups(P>0.05).Compared with T_(1),the levels of CRP,total bilirubin(TBil)and direct bilirubin(DB)at T_(3)in the 2 groups were significantly higher,and the UREA level at T_(3)was significantly lower,with statistical significance(P<0.05),but there were no statistical significance in the levels of CRP,TBil and DB between the 2 groups at T_(3)(P>0.05).At T_(3),the alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in control group were significantly higher than those at T_(1)and T_(3)in observation group,with statistical signif

关 键 词：腹腔镜手术 围术期 血必净注射液 炎性反应 器官功能 

分 类 号：R656[医药卫生—外科学]