高良姜素丙烯酸树脂纳米粒的制备及工艺优化  

Preparation and Process Optimization of Galangin Loaded Eudragit?RS100 Nanoparticles

作　　者：熊远果 郭咸希[1] 宋伟 沈瑶[1] 张璐[1] 张洪[1] Xiong Yuanguo;Guo Xianxi;Song Wei;Shen Yao;Zhang Lu;Zhang Hong(Department of Pharmacy,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院药学部,武汉430060

出　　处：《中国药师》2022年第9期1551-1557,共7页China Pharmacist

基　　金：湖北省卫生健康委科研项目(编号:WJ2021M147)。

摘　　要：目的:为改善高良姜素溶解性和提高其生物利用度,研制高良姜素丙烯酸树脂纳米粒(GA-NPs)并进行工艺优化。方法:采用纳米制备法制备GA-NPs,结合超声乳化对制备方法进行优化,以纳米粒粒径、多聚分散指数及Zeta电位为主要指标,通过单因素、正交试验优化制备工艺及处方,并进行验证。结果:优化后的处方工艺为药载比1∶150,有机相和水相比例1∶2,吐温80用量1.0%,超声时间10 min。制备的GA-NPs粒径为(70.98±1.44)nm,PDI为0.181±0.003,Zeta电位为(63.20±1.60)mV,包封率为(97.90±0.58)%。结论:优化的处方工艺制备的高良姜素纳米粒粒径大小适中,分布均匀,包封率较高,适用于GA-NPs制备。Objective:To prepare and optimize the preparation process of galangin loaded Eudragit?RS100 nanoparticles(GA-NPs),so as to overcome the limitations of galangin in solubility and bioavailability.Methods:GA-NPs were prepared with a nanopreparation method,and optimized by ultrasonic emulsification.Based on the results of single factor experiments,four main factors affecting the formulation were optimized by orthogonal design depending on the mean size,polydispersity index and Zeta potential.Results:The optimal formulation of nanoparticles was as follows:the drug loading ratio was 1∶50,the ratio of organic phase to aqueous phase was 1∶2,the amount of tween 80 was 1.0%,and the ultrasonic time was 10 min.GA-NPs were prepared with the optimized emulsion method,the mean size was about(70.98±1.44)nm,polydispersity index was 0.181±0.003,Zeta potential was(63.20±1.60)mV,and the encapsulation efficiency was(97.90±0.58)%.Conclusion:The prepared nanoparticles are with appropriate particle size,uniform distribution and high entrapment efficiency,indicating the optimized ultrasonic emulsification method is suitable for the preparation of GA-NPs.

关 键 词：高良姜素 纳米粒 丙烯酸树脂 工艺优化 

分 类 号：R944.9[医药卫生—药剂学]