胃肠道疾病与菌群治疗  

Gastrointestinal Diseases and Gut Microbiome Therapy

作　　者：黄子誉 左涛 兰平 HUANG Ziyu;ZUO Tao;LAN Ping(Guangdong Institute of Gastroenterology,Guangzhou 510655,China;Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510655,China;Department of Colorectal Surgery,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510655,China)

机构地区：[1]广东省胃肠病学研究所,广州510655 [2]中山大学附属第六医院广东省结直肠盆底疾病研究重点实验室,广州510655 [3]中山大学附属第六医院结直肠肛门外科,广州510655

出　　处：《协和医学杂志》2022年第5期732-739,共8页Medical Journal of Peking Union Medical College Hospital

基　　金：国家自然科学基金(U21A20344,82172323,32100134);国家临床重点专科项目;广州市科技计划项目(202206010014)。

摘　　要：肠道菌群通过其代谢物、分泌物或细胞成分参与调节宿主代谢和免疫,并保护宿主抵抗病原微生物入侵。环境、营养、生活习惯改变以及抗生素滥用等原因均可导致肠道微生态结构和功能失调,进而导致多种疾病。与此同时,肠道菌群亦成为极具潜力的疾病治疗手段。本文将对胃肠道疾病(包括胃肠道感染性疾病、炎症性肠病、肠易激综合征等)与菌群的关系以及基于肠道菌群治疗该类疾病的最新研究成果进行总结,并对肠道菌群在未来疾病预防和干预中的前景作出展望。Gut microbiome regulates host metabolism and immunity via their metabolites,secretions,and cellular components,and protects the host from pathogen invasion.Low diversity and dysfunction of the gut microbiome caused by environmental changes,unhealthy dietary habits and lifestyles,and antibiotics abuse are closely related to disease pathogenesis.Gut microbiome can serve as diagnostic and therapeutic tools for diseases related to gut microbiome dysbiosis.In this article,we aim to review the latest study advances on gut microbiome in the pathogenesis and therapeutics of gastrointestinal diseases,such as Clostridium difficile infection,Helicobacter pylori infection,inflammatory bowel disease,and irritable bowel syndrome,so as to shed light on the prospect of gut microbiome modulations in disease therapies.

关 键 词：肠道菌群 微生态 胃肠道疾病 治疗 粪便微生物移植 

分 类 号：R37[医药卫生—病原生物学]