昼夜节律调节耳蜗对噪声敏感性研究进展  

Research progress of the regulation of cochlear sensitivity to noise by circadian rhythm

作　　者：金宝玲 吴菁 崔钟丹 唐佳[1] 陈其才[1] 付子英[1] JIN Bao-Ling;WU Jing;CUI Zhong-Dan;TANG Jia;CHEN Qi-Cai;FU Zi-Ying(School of Life Sciences and Hubei Key Laboratory of Genetic Regulation and Integrative Biology,Central China Normal University,Wuhan 430079,China)

机构地区：[1]华中师范大学生命科学学院,遗传调控与整合生物学湖北省重点实验室,武汉430079

出　　处：《生理学报》2022年第3期489-494,共6页Acta Physiologica Sinica

基　　金：supported by the Natural Science Foundation of Hubei Province;China(No.2019CFB758);the National Natural Science Foundation of China(No.31772454);the Fundamental Research Funds of Central China Normal University(No.CCNU20TS018)。

摘　　要：强烈的噪声会损伤耳蜗毛细胞、听神经、耳蜗毛细胞与听神经之间的突触连接,造成噪声性听力损失(noise-induced hearingloss,NIHL)。近年来的研究显示,动物耳蜗具有昼夜节律性,使得它们对昼夜噪声的敏感性不同。耳蜗昼夜节律与脑源性神经营养因子以及糖皮质激素水平之间存在着一定的关系,从而影响动物噪声暴露后听力损失的程度。本文综述了昼夜节律调节耳蜗对噪声敏感性研究进展,并对未来的研究方向进行了展望。High level noise can damage cochlear hair cells,auditory nerve and synaptic connections between cochlear hair cells and auditory nerve,resulting in noise-induced hearing loss(NIHL).Recent studies have shown that animal cochleae have circadian rhythm,which makes them different in sensitivity to noise throughout the day.Cochlear circadian rhythm has a certain relationship with brain-derived neurotrophic factor and glucocorticoids,which affects the degree of hearing loss after exposure to noise.In this review,we summarize the research progress of the regulation of cochlear sensitivity to noise by circadian rhythm and prospect the future research direction.

关 键 词：噪声性听力损失 昼夜节律 脑源性神经营养因子 糖皮质激素 生物钟 

分 类 号：R339.16[医药卫生—人体生理学]