冲击剂量甲泼尼龙琥珀酸钠联合常规治疗对小儿重症支原体肺炎的疗效观察  

Efficacy observation of shock-dose methylprednisolone sodium succinate combined with conventional treatment on children with severe mycoplasma pneumonia

作　　者：周英杰 ZHOU Ying-jie(Department of Intensive Medicine,Shenyang Children's Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市儿童医院重症医学科,110000

出　　处：《中国现代药物应用》2022年第16期136-138,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探究冲击剂量甲泼尼龙琥珀酸钠与常规疗法联合治疗小儿重症支原体肺炎的疗效。方法133例小儿重症支原体肺炎患儿为研究对象,依据随机数字表法分为对照组(67例)与观察组(66例)。两组均进行常规治疗,在此基础上,观察组应用冲击剂量的甲泼尼龙琥珀酸钠治疗,对照组应用常规剂量的甲泼尼龙琥珀酸钠治疗。比较两组治疗效果、临床症状消失时间及不良反应发生情况。结果观察组治疗总有效率96.97%高于对照组的85.07%,差异有统计学意义(P<0.05)。观察组发热消失时间、咳嗽消失时间和肺啰音消失时间分别为(1.28±0.33)、(4.68±0.78)、(7.20±1.15)d,均短于对照组的(3.10±0.56)、(7.20±1.25)、(11.23±2.13)d,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论冲击剂量甲泼尼龙琥珀酸钠在小儿重症支原体肺炎治疗中疗效肯定,有助于促进患儿炎症反应的控制和临床症状的缓解,且不良反应少,值得推广。Objective To investigate the efficacy of shock-dose methylprednisolone sodium succinate combined with conventional treatment on children with severe mycoplasma pneumonia.Methods A total of 133 children with severe mycoplasma pneumonia were selected as the research subjects,and they were divided into the control group(67 cases)and the observation group(66 cases)according to the random numerical table.Both groups received conventional treatment.On this basis,the observation group was treated with shock dose of methylprednisolone sodium succinate,and the control group was treated with conventional dose of methylprednisolone sodium succinate.The therapeutic effect,disappearance time of clinical symptoms and occurrence of adverse reactions were compared between the two groups.Results The total effective rate 96.97%of the observation group was higher than 85.07%of the control group,and the difference was statistically significant(P<0.05).The disappearance time of fever,cough disappearance time and lung rales disappearance time in the observation group were(1.28±0.33),(4.68±0.78)and(7.20±1.15)d,which were shorter than(3.10±0.56),(7.20±1.25)and(11.23±2.13)d in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Shock-dose methylprednisolone sodium succinate is effective in the treatment of severe mycoplasma pneumonia in children.It helps to promote the control of inflammatory response and the remission of clinical symptoms in children,with less adverse reactions,which is worth promoting.

关 键 词：小儿重症支原体肺炎 冲击剂量甲泼尼龙琥珀酸钠 炎症反应 临床症状 

分 类 号：R725.6[医药卫生—儿科]