银杏达莫注射液制备工艺优化研究  

Optimization of Preparation Technology for Ginkgo Diphytidamole Injection

作　　者：马海霞 杨广安[1] 廖大敏[1] 谭琪明[1] 罗杰[1,2] MA Hai-xia;YANG Guang-an;LIAO Da-min;TAN Qi-ming;LUO Jie(Tongren Polytechnic College,Tongren Guizhou 554300,China;Tongren Pharmaceutical Cuisine Industry Engineering Technology Research Center,Tongren Guizhou 554300,China)

机构地区：[1]铜仁职业技术学院,贵州铜仁554300 [2]铜仁市药膳产业工程技术研究中心,贵州铜仁554300

出　　处：《辽宁化工》2022年第9期1244-1247,共4页Liaoning Chemical Industry

基　　金：铜仁市基础科学研究计划项目(项目编号:铜市科研〔2021〕54号);铜仁职业技术学院自然科学项目(项目编号:tzky-2021年-ZK11号);民族特色药用资源开发与应用创新团队(项目编号:铜职院办发〔2020〕118号);民族中兽药分离纯化技术国家地方联合工程研究中心创新创业项目(项目编号:GJGCZC-1912号)。

摘　　要：目的:优化银杏达莫注射液制备工艺。方法:以银杏总黄酮含量、双嘧达莫含量、外观等为指标,对原料药银杏叶提取物进行筛选,对注射液溶媒、助溶剂、抗氧化剂、活性炭吸附作用、注射液pH值选择等进行工艺优化研究。结果:水溶性银杏叶提取物为原料;注射用水为溶媒;丙二醇为助溶剂;焦亚硫酸钠为抗氧化剂;活性炭吸附热原,脱色助滤;pH值控制在4.2~4.3。结论:该优化工艺质量稳定可控,为大生产提供可靠依据。In order to optimize the preparation process of ginkgo diphytidamole injection,the extract of ginkgo biloba leaves was screened by taking the total flavonoid content of ginkgo biloba,dipyridamole content and appearance as indicators,and the injection solvent,cosolvent,antioxidant,adsorption of activated carbon and pH value of injection was studied.The results showed that optimized process conditions were as follows:using water soluble ginkgo leaf extract as raw material,using injection water as injection solvent,using propylene glycol as cosolvent,using sodium metabisulfite as antioxidant,using activated carbon to adsorb pyrogen for improving the clarity of products,adjusting the pH value of injection to 4.2~4.3.The optimized process quality was stable and controllable,providing reliable basis for mass production.

关 键 词：银杏达莫注射液 制备工艺优化 水溶性银杏叶提取物 稳定性 

分 类 号：TQ460[化学工程—制药化工]