阿奇霉素联合左氧氟沙星门诊治疗慢性支气管炎急性发作效果分析  

Effects Analysis of Azithromycin Combined with Levofloxacin in the Ambulatory Treatment of Acute Attack of Chronic Bronchitis

作　　者：刘红杰 侯丽超 相玲丽 李春梅[2] 姚俊功 LIU Hongjie;HOU Lichao;XIANG Lingli;LI Chunmei;YAO Jungong(Department of Critical Medicine,The Third Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450052,China;Department of Adult Medicine,The Third Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450052,China)

机构地区：[1]郑州大学第三附属医院重症医学科,河南郑州450052 [2]郑州大学第三附属医院成人内科,河南郑州450052

出　　处：《临床研究》2022年第10期89-92,共4页Clinical Research

摘　　要：目的探究慢性支气管炎急性发作时开展左氧氟沙星联合阿奇霉素治疗的作用。方法选择郑州大学第三附属医院门诊2019年1月至2022年1月收治的80例慢性支气管炎急性发作期患者。按照治疗方法不同分为当作常规组(40例)及试验组(40例),将阿奇霉素应用于常规组患者中,将左氧氟沙星联合阿奇霉素应用于试验组患者中。针对每组患者治疗效果、各时期血清炎性因子水平、临床表现改善时间、肺功能指标水平、不良反应进行比较。结果试验组与常规组患者治疗有效率依次是95.00%、75.00%,差异有统计学意义(P<0.05)。同组组内用药后白细胞介素-8、白细胞介素-6及肿瘤坏死因子-α水平均低于用药前,用药后试验组患者白细胞介素-8、白细胞介素-6及肿瘤坏死因子-α水平均低于常规组,差异有统计学意义(P<0.05)。试验组患者呼吸困难、咳嗽及发热症状改善时间均短于常规组,差异有统计学意义(P<0.05)。同组组内用药后呼气峰值流速、第1 s用力呼气量及第1 s用力呼气量/用力肺活量水平相较用药前高,用药后试验组患者呼气峰值流速、第1 s用力呼气量及第1 s用力呼气量/用力肺活量水平相较常规组高,差异有统计学意义(P<0.05)。试验组与常规组患者不良反应出现率依次是12.50%、10.00%,差异无统计学意义(P>0.05)。结论慢性支气管炎急性发作时开展左氧氟沙星联合阿奇霉素治疗,能够降低炎性因子水平,改善临床症状,提高肺功能,同时不良反应较少,安全性良好。Objective To explore the effects of Levofloxacin and Azithromycin in the ambulatory treatment of acute attack of chronic bronchitis.Methods A total of 80 acute attack of chronic bronchitis patients treated in our hospital from January 2019 to January 2022 were selected.According to the treatment method,patients were divided into routine group(N=40)and experimental group(N=40).Azithromycin was applied in the routine group;Levofloxacin combined with Azithromycin were applied in the experimental group.The curative effects,clinical symptom improvement time,adverse reactions,serum inflammatory factors and lung function indicators were compared.Results The total effective rate in the experimental group and routine group was 95.00% and 75.00%,respectively(P<0.05);After medication,interleukin-8,interleukin-6 and tumor necrosis factor-α levels for two groups were lower than before;interleukin-8,interleukin-6 and tumor necrosis factor-αlevels in the experimental group were even lower than routine group(P<0.05);The amelioration time of breathing difficulty,cough and fever in the experimental group was shorter than routine group(P<0.05);After medication,the peak expiratory flow,forced expiratory volume in one second and forced expiratory volume in one second to forced vital capacity ratio in two groups were higher than before;after medication,the peak expiratory flow,forced expiratory volume in one second and forced expiratory volume in one second to forced vital capacity ratio in the experimental group were even higher than routine group(P<0.05).The total adverse drug rate in the experimental group and routine group was 12.50% and 10.00%,respectively(P>0.05).Conclusion Levofloxacin combined with Azithromycin can reduce the clinical symptoms,inflammatory factors and adverse reactions,improve the lung function and treatment safety for acute attack of chronic bronchitis patients.

关 键 词：急性发作 慢性支气管炎 左氧氟沙星 阿奇霉素 炎性因子 肺功能 

分 类 号：R562.21[医药卫生—呼吸系统]