1990~2019年中国及全球非风湿性钙化性主动脉瓣疾病负担研究  

The Disease Burden and Risk Factors of Non-rheumatic Calcific Aortic Valve Disease in China and the World From 1990 to 2019

作　　者：王梦龙[1] 潘威 徐瑶[1] 张记收 万军[1] WANG Menglong;PAN Wei;XU Yao;ZHANG Jishou;WAN Jun(Department of Cardiology,Renmin Hospital of Wuhan University,Cardiovascular Research Institute,Hubei Key Laboratory of Cardiology,Wuhan(430060),Hubei,China)

机构地区：[1]武汉大学人民医院心内科,武汉大学心血管病研究所,心血管病湖北省重点实验室,湖北省武汉市430060

出　　处：《中国循环杂志》2022年第9期907-913,共7页Chinese Circulation Journal

基　　金：国家自然科学基金(82070436、82100292)。

摘　　要：目的:探讨1990~2019年中国及全球非风湿性钙化性主动脉瓣疾病(NR-CAVD)负担及其危险因素的变化。方法:基于2019年全球疾病负担研究(GBD)数据库获取中国及全球NR-CAVD数据,通过发病率、患病率、死亡率、伤残调整寿命年(DALY)等指标对1990~2019年中国及全球NR-CAVD疾病负担变化趋势进行描述,并分析其危险因素的变化情况。结果:2019年,中国NR-CAVD的患病人数、新发病例人数和死亡人数分别为86.8[95%不确定区间(UI):68.8~106.5]万例、5.5(95%UI:4.4~6.7)万例和2799(95%UI:2225~3396)例,患病人数和新发病例人数最多的年龄段分别为65~69岁和55~59岁。2019年中国NR-CAVD的年龄标化患病率和发病率分别为42.7(95%UI:34.0~52.1)/10万和2.6(95%UI:2.1~3.2)/10万,且男性的年龄标化患病率、发病率均高于女性。1990~2019年,中国和全球NR-CAVD的年龄标化患病率及发病率均呈持续上升趋势,年龄标化死亡率相对稳定,而DALY率呈下降趋势,且中国NR-CAVD的疾病负担低于全球整体水平。与NR-CAVD死亡相关的危险因素主要是高收缩压、高钠饮食和铅暴露,中国人群中高收缩压导致的NR-CAVD死亡比例已高于全球整体水平且仍在持续上升。结论:1990~2019年,中国NR-CAVD的年龄标化患病率及发病率均呈持续上升趋势,年龄标化死亡率相对稳定,而DALY率呈下降趋势。随着人口老龄化进展,中国NR-CAVD的疾病负担将日益严峻,应采取积极的防治措施以降低NR-CAVD疾病负担。Objectives:To explore the changes in the disease burden and risk factors of non-rheumatic calcific aortic valve disease(NR-CAVD)in China and the world from 1990 to 2019.Methods:The Chinese and global NR-CAVD data were obtained from the 2019 Global Burden of Disease(GBD)database.The morbidity,prevalence,mortality,disability-adjusted life years(DALY)and other indicators were used to compare the disease burden of China and the world from 1990 to 2019.In addition,the risk factors of NR-CAVD and their changes were analyzed.Results:In 2019,the number of patients,new cases and deaths of NR-CAVD in China were 868(95%uncertainty interval[UI]:688-1065)thousand,55(95%UI:44-67)thousand,and 2799(95%UI:2225-3396),respectively.The age groups with the largest number of patients and new cases were 65-69 years old and 55-59 years old,respectively.The agestandardized prevalence and incidence of NR-CAVD in China in 2019 were 42.7(95%UI:34.0-52.1)/100000 and 2.6(95%UI:2.1-3.2)/100000,respectively,and the standardized prevalence and incidence rate were higher in male than in female.From 1990 to 2019,the age-standardized prevalence and incidence of NR-CAVD in China and the world have shown a continuous upward trend,while the age-standardized mortality and DALY rate have shown a downward trend.The disease burden of NR-CAVD in China is lower than the global level.The main risk factors associated with NR-CAVD death are high systolic blood pressure,high sodium diet and lead exposure.The proportion of NR-CAVD deaths caused by high systolic blood pressure in the Chinese population has exceeded the global level and is still rising.Conclusions:From 1990 to 2019,the age-standardized prevalence and incidence of NR-CAVD in China showed a continuous upward trend,while the age-standardized mortality and DALY rate showed a downward trend.With the progress of aging,the disease burden of NR-CAVD in China will continuously increase,and active prevention and control measures should be taken to reduce the burden of NR-CAVD in China and the world.

关 键 词：瓣膜性心脏病 患病率 发病率 疾病负担 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]