基于“肠道菌群”探讨从脾肾论治原发性骨质疏松症科学内涵  

Discussion on the Scientific Connotation of Treating Primary Osteoporosis from Spleen and Kidney Based on“Gut Microbiota”

作　　者：沈波 杨鸫祥[2] 那俊夫 李琦 SHEN Bo;YANG Dongxiang;NA Junfu;LI Qi(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2022年第4期201-205,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：辽宁省科学技术计划项目(2020JH2/10300068);沈阳市中青年科技创新人才支持计划项目(RC180309);辽宁中医药大学中医脏象理论及应用国家教育部重点实验室开放基金课题(ZYZX1806)。

摘　　要：随着我国人口老龄化程度加剧,骨质疏松症的发病率逐年增高,其防治俨然成为不可忽视的社会问题。中医基于脏腑理论,从脾肾论治骨质疏松症,疗效显著,但其作用机制未得到完全阐明。中医古籍记载脾肾二脏象能影响肠腑生理功能,现代研究也发现脾肾与肠道微生态稳定密切相关,而现有研究又发现肠道菌群与骨质疏松症之间存在密切联系。故该文从肠道菌群出发,阐述脾肾脏象与骨质疏松症间的联系,期望为从脾肾论治原发性骨质疏松症的机制研究提供重要参考。With the increasing aging of population,the incidence rate of osteoporosis is increasing year by year.Prevention and cure of it has become a social problem that can not be neglected.Based on the theory of viscera,traditional Chinese medicine treats osteoporosis from the spleen and kidney.The curative effect is remarkable,but its mechanism has not been fully elucidated.Ancient Chinese medicine records that spleen and kidney can affect the physiological function of intestines.Modern studies have also found that the spleen and kidney are closely related to the stability of intestinal microecology,and existing studies have found that there is a close relationship between gut microbiota and osteoporosis.This paper,starting from gut microbiota,expounds the relationship between spleen and kidney and osteoporosis,hoping to provide an important reference for the mechanism research of treating primary osteoporosis from spleen and kidney.

关 键 词：肠道菌群 脾肾脏象 骨质疏松症 

分 类 号：R714.257[医药卫生—妇产科学]