间充质干细胞对肝硬化进展的调控机制  

Regulating Mechanism of Mesenchymal Stem Cells on the Progression of Liver Cirrhosis

作　　者：罗筱凡 罗业浩 吕挺 吴笛 李宏一 段雪琳[1] LUO Xiaofan;LUO Yehao;LYU Ting;WU Di;LI Hongyi;DUAN Xuelin(Guangxi University of Traditional Chinese Medicine,Nanning 530200,Guangxi,China;Hubei University for Nationalities,Enshi 445000,Hubei,China)

机构地区：[1]广西中医药大学,广西南宁530200 [2]湖北民族大学,湖北恩施445000

出　　处：《辽宁中医药大学学报》2022年第8期65-69,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81973976);广西医学高层次骨干人才培养“139”计划资助项目(桂卫科教发[2020]15号);广西中医药大学一流学科建设开放课题资助项目(2019XK040)。

摘　　要：肝硬化为临床常见多发疾病。近年来,越来越多研究发现间充质干细胞在肝脏疾病治疗方面具有一定的临床价值,尤其是在阻断肝硬化进程和减轻肝硬化程度的临床应用前景光明。间充质干细胞可以分化为肝细胞或肝干细胞,尤其是通过旁分泌机制,可有效促进肝再生、抑制肝纤维化及抗肝细胞凋亡,对于治疗肝硬化有重大意义。间充质干细胞在治疗肝硬化中具有重要价值,是潜在的诊断和治疗的标志物,文章将重点探讨间充质干细胞对肝硬化的发展及治疗中的作用机制,进一步提高间充质干细胞的应用和治疗定量的标准化制定。Liver cirrhosis is a common clinical disease.In recent years,more and more studies have found that mesenchymal stem cells have a certain clinical value in the treatment of liver diseases,especially in the clinical application of blocking the process of liver cirrhosis and reducing the degree of liver cirrhosis.Mesenchymal stem cells can differentiate into hepatocytes or hepatic stem cells,especially through the paracrine mechanism,which can effectively promote liver regeneration,inhibit liver fibrosis and induce liver apoptosis.It is of great significance for the treatment of liver cirrhosis.Mesenchymal stem cells have important value in the treatment of liver cirrhosis and are potential diagnostic and therapeutic markers.This article will focus on exploring the mechanism of action of mesenchymal stem cells on the development and treatment of liver cirrhosis,so as to further improve the performance of mesenchymal stem cells and standardization of application and treatment quantification.

关 键 词：间充质干细胞 肝硬化 调控机制 综述 

分 类 号：R657.31[医药卫生—外科学]