龙藤降压汤对高血压焦虑抑郁患者的影响  

Observation of the Effect of Longteng Jiangya Decoction(龙藤降压汤) on Patients with Hypertension Anxiety and Depression

作　　者：陈会娟[1] 张英泽[1] 范凌云 要丹丹 尚静 时英菊 范新发[1] CHEN Huijuan;ZHANG Yingze;FAN Lingyun;YAO Dandan;SHANG Jing;SHI Yingju;FAN Xinfa(Baoding First Hospital of Traditional Chinese Medicine,Baoding 071028,Hebei,China)

机构地区：[1]保定市第一中医院,河北保定071028

出　　处：《辽宁中医药大学学报》2022年第8期106-110,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划(2021275)。

摘　　要：目的观察龙藤降压汤对高血压焦虑抑郁患者的影响。方法选择2020年7月—2021年5月于医院治疗的80例高血压焦虑抑郁患者为研究对象,以随机数字表法对患者分组,40例患者为研究组,40例患者为对照组,对照组给予苯磺酸左旋氨氯地平片治疗,研究组在对照组基础上给予自拟龙藤降压汤治疗,治疗前、后检查两组患者5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)、外周血干细胞因子(SCF)及其抗体水平(c-kit)、促甲状腺激素(TSH)、皮质醇(Cor)、促肾上腺皮质激素(ACTH)、醛固酮(ALD)、血管紧张素Ⅱ(AngⅡ)、平均舒张压、平均收缩压、24 h舒张压变异、24 h收缩压变异水平,采用贝克焦虑量表(BAI)评价两组患者焦虑症状,采用贝克抑郁量表(BDI)评价患者抑郁症状,采用匹兹堡睡眠质量指数(PSQI)检测患者睡眠质量,采用生活质量综合评定问卷(GQOLI-74)评价两组患者生活质量,比较两组临床疗效。结果研究组5-HT、DA、NE水平高于对照组(P<0.05),研究组ALD、AngⅡ水平低于对照组(P<0.05),研究组SCF、c-kit水平高于对照组(P<0.05),研究组Cor、ACTH水平低于对照组(P<0.05),研究组TSH水平高于对照组(P<0.05),研究组平均舒张压、平均收缩压、24 h舒张压变异、24 h收缩压变异水平低于对照组(P<0.05),研究组患者BAI、BDI、PSQI评分低于对照组(P<0.05),研究组GQOLI-74评分水平高于对照组(P<0.05),研究组总有效率高于对照组(75.00%VS 95.00%)(P<0.05)。结论龙藤降压汤干预青年高血压焦虑抑郁患者,可提升改善神经递质,提升SCF、c-kit水平,降低ALD水平,调节患者神经内分泌指标,降低血压变异性,改善焦虑、抑郁症状,提升患者睡眠质量及生活质量,提升临床疗效。Objective To observe the effect of Longteng Jiangya Decoction(龙藤降压汤)on patients with hypertension anxiety and depression.Methods 80 patients with hypertension anxiety and depression treated in our hospital from July 2020 to May 2021 were selected as the research object.The patients were divided into groups by random number table method.40 patients were the research group and 40 patients were the control group.The control group was treated with L-amlodipine besylate tablets,and the research group was treated with self-made Longteng Jiangya Decoction on the basis of the control group.The levels of serotonin(5-HT),norepinephrine(NE),dopamine(DA),peripheral blood stem cell factor(SCF)and its antibody(c-kit),thyroid stimulating hormone(TSH),cortisol(COR),adrenocorticotropic hormone(ACTH),aldosterone(ALD),angiotensin Ⅱ(AngⅡ),mean diastolic blood pressure,mean systolic blood pressure,24 h diastolic blood pressure variation The level of 24-hour systolic blood pressure variation was evaluated by Baker Anxiety Scale(BAI),depression by Baker Depression Scale(BDI),sleep quality by Pittsburgh sleep quality index(PSQI),and quality of life by comprehensive quality of life questionnaire(GQOLI-74).Results The levels of 5-HT,DA and NE in the study group were higher than those in the control group(P<0.05),the levels of ALD and AngⅡ in the study group were lower than those in the control group(P<0.05),the levels of SCF and c-kit in the study group were higher than those in the control group(P<0.05),the levels of Cor and ACTH in the study group were lower than those in the control group(P<0.05),and the levels of TSH in the study group were higher than those in the control group(P<0.05).The 24-hour diastolic blood pressure variability and 24-hour systolic blood pressure variability of the study group were lower than those of the control group(P<0.05),the BAI,BDI and PSQI scores of the study group were lower than those of the control group(P<0.05),and the GQOLI-74 score of the study group was higher than that of the con

关 键 词：龙藤降压汤 青年 高血压焦虑抑郁 神经内分泌 血压变异性 神经递质 

分 类 号：R277.7[医药卫生—中医学]