轻度创伤性脑损伤急性期及亚急性期局部自发脑活动改变的元分析  

Meta-analysis of local spontaneous brain activity changes in acute and subacute mild traumatic brain injury

作　　者：袁文欢 罗琳[1] 王云玲 金涛 喻大华 YUAN Wenhuan;LUO Lin;WANG Yunlin;JIN Tao;YU Dahua(Department of Imaging,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014000,China;Key Laboratory of Pattern Recognition and Intelligent Image Processing,School of Information Engineering,Inner Mongolia University of Science and Technology,Baotou 014000,China)

机构地区：[1]内蒙古科技大学包头医学院第一附属医院影像科,包头014000 [2]内蒙古科技大学信息工程学院模式识别与智能图像处理重点实验室,包头014000

出　　处：《磁共振成像》2022年第9期13-17,24,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：内蒙古自治区教育厅项目(编号:S20210171Z);内蒙古包头市卫生健康科技计划项目(编号:wsjkkj005)。

摘　　要：目的探讨静息态功能磁共振成像(resting state functional magnetic resonance imaging,rs-f MRI)研究轻度创伤性脑损伤(mild traumatic brain injury,m TBI)最为一致的易损区域,揭示m TBI潜在的大脑神经机制。材料与方法检索2022年3月以前采用局部一致性(regional homogeneity,Re Ho)、低频波动幅度(amplitude of low-frequency fluctuation,ALFF)及分数低频波动振幅(fraction amplitude of low-frequency fluctuation,fALFF)方法探讨mTBI静息态大脑激活异常改变的研究。汇总既往研究中mTBI患者相对于健康被试局部自发脑活动异常的脑区,且采用标记差异映像(signed differential mapping,SDM)软件进行数据分析。结果共纳入11篇研究(401例mTBI,371例健康对照)。基于元分析证实mTBI患者右侧舌回、左侧枕中回、右侧背外侧额上回和左侧中央沟盖的局部自发脑活动明显升高;左侧前扣带和旁扣带回、右侧角回和左侧额中回的局部自发脑活动降低(P<0.005,峰高Z>1,簇范围≥20个体素)。结论应用元分析证实了mTBI患者相关核心脑功能异常的脑区。这些发现有助于划定特定感兴趣区域和理解mTBI的神经生物学基础。Objective:To explore the most consistent vulnerable regions of mild traumatic brain injury(mTBI)studied by resting state functional magnetic resonance imaging(rs-fMRI),and to reveal the underlying neural mechanism of mTBI.Materials and Methods:A search was performed for studies on mTBI resting state brain activation abnormalities by regional homogeneity(ReHo),amplitude of low-frequency fluctuation(ALFF)and fraction amplitude of low-frequency fluctuation(fALFF)before March 2022.The brain regions with abnormal local spontaneous brain activity in mTBI patients compared with healthy subjects in previous studies were summarized,and the signed differential mapping(SDM)software was used for data processing and analysis.Results:A total of 11 studies(401 mTBI and 371 healthy controls)were included.Based on meta-analysis,it was confirmed that mTBI patients had significantly increased local spontaneous brain activity in right lingual gyrus,left middle occipital gyrus,right dorsolateral superior frontal gyrus and left central sulcus.Local spontaneous brain activity was decreased in the left anterior cingulate and paracingulate gyrus,right angular gyrus and left middle frontal gyrus(P<0.005,peak height Z>1,cluster extent≥20 voxels).Conclusions:Meta-analysis was used to confirm the abnormal core brain regions in mTBI patients.These findings help delineate specific areas of interest and understand the neurobiological basis of mTBI.

关 键 词：轻度创伤性脑损伤 局部自发脑活动 元分析 标记差异映射分析 静息态功能磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R651.1[医药卫生—诊断学]