黑素体在黑素细胞内运输及调控机制的研究进展  

Research advances in mechanism of melanosomes transport and regulation in melanocytes

作　　者：宁婧 张汝芝[1] NING Jing;ZHANG Ru-zhi(Department of Dermatology,the Third Affiliated Hospital of Soochow University,Changzhou 213003,China)

机构地区：[1]苏州大学附属第三医院皮肤性病科,江苏常州213003

出　　处：《基础医学与临床》2022年第10期1581-1584,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(81673078);中华医学会项目(S2018151137);江苏省双创计划([2015]26);常州市医学重点学科建设项目([2018]161⁃7);常州市医学创新人才培养项目([2016]27⁃4)。

摘　　要：黑素体(MS)是黑素细胞(MC)中一种合成、储存和运输黑素的特殊膜性细胞器,其类型、数量、分布及成熟状态决定了人类肤色的差异。MS在MC内的运输是3种动力蛋白与两种细胞骨架之间相互作用的结果,此过程受多种调节因素影响。MS运输障碍与多种色素性疾病相关,加深对MS运输机制的了解有助于提高对MS运输障碍相关性疾病的认识,为临床治疗和药物研发提供新依据。Melanosome(MS)is a special membrane organelle which synthesizes,stores and transports melanin in melanocytes(MC).The diversity of human skin color lies on the type,quantity,distribution and maturation of MS.The transport of MS in MC is the result of the interaction between three kinesins and two kinds of cytoskeletons,which are affected by many regulatory factors.A variety of pigmented diseases are strongly associated with MS trans⁃port malfunction.A deeper understanding of the mechanism for MS transport may improve the cognition of MS trans⁃port⁃related diseases and potentially provide a novel strategy for clinical treatment and pharmaceutical development.

关 键 词：黑素体运输 微管 肌动蛋白微丝 驱动蛋白 肌球蛋白⁃Va 

分 类 号：R334.5[医药卫生—人体生理学] R751[医药卫生—基础医学]