A型肉毒毒素治疗雷诺现象的研究进展  

Research progress on botulinum toxin type A in the treatment of Raynaud’s phenomenon

作　　者：王远卓 郑清月 张翰林 唐珂韵 房柔妤 孙秋宁[1] WANG Yuan-zhuo;ZHENG Qing-yue;ZHANG Han-lin;TANG Ke-yun;FANG Rou-yu;SUN Qiu-ning(Department of Dermatology,Peking Union Medical College Hospital,CAMS&PUMC,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院皮肤科,北京100730

出　　处：《基础医学与临床》2022年第10期1611-1615,共5页Basic and Clinical Medicine

摘　　要：雷诺现象是一种常见的血管痉挛反应,现有药物和手术治疗的临床效果有限。A型肉毒毒素治疗雷诺现象具有一定有效性和安全性。它能舒张血管、缓解疼痛,具有较好的远期疗效,而不良反应轻微,如注射部位疼痛、瘀斑或一过性肌肉无力。近年来,该治疗的适用范围进一步扩展,有效的注射剂量和注射方法得以确定,治疗相关的不良反应得以减少。还需大样本随机双盲对照试验和动物实验研究为深入阐明其机制和疗效提供依据。Raynaud’s phenomenon is a common vasospasm response, and current medical therapies and surgical treatments show limited clinical effects. Botulinum toxin type A has certain effectiveness and safety in treating Raynaud’s phenomenon. It can relax blood vessels, relieve pain, and has a good long-term effect. Its side effects are mild, such as pain at the injection site, bruises, or transient muscle weakness. In recent years, some research has broadened the scope of application of the treatment and determined more effective injection doses and injection methods to reduce the side effects. More large-sample randomized double-blind controlled trials and animal experiments are needed to provide information for explaining the treatment mechanisms and illstrating the efficacy.

关 键 词：雷诺现象 A型肉毒毒素 

分 类 号：R816.95[医药卫生—放射医学]