湖南省既往HIV-2疑似感染者血清流行病学调查  

HIV-2 sero-prevalence in Hunan province,China

作　　者：郑军[1] 彭瑾瑜[1] 贺健梅[1] 粟晓玲[2] 邹潇白[1] 江洋[1] 陈曦[1] Zheng Jun;Peng Jinyu;He Jianmei;Su Xiaoling;Zou Xiaobai;Jiang Yang;Chen Xi(Hunan Provincial Center for Disease Control and Prevention,Changsha 410005,China)

机构地区：[1]湖南省疾病预防控制中心,长沙410005 [2]湖南省湘潭市疾病预防控制中心,湘潭411100

出　　处：《中华实验和临床病毒学杂志》2022年第4期424-428,共5页Chinese Journal of Experimental and Clinical Virology

基　　金：湖南省自然科学基金(2019JJ40158);国家科技重大专项(2017ZXl0201101-002-009)。

摘　　要：目的通过对湖南省既往HIV-2疑似感染者血清样本进行HIV-2抗体检测和流行病学调查,了解湖南省HIV-2感染状况。方法收集全省15家艾滋病确证实验室2003—2020年原始记录中出现了HIV-2抗体指示性条带的库存血样和检测对象流行病学资料,采用国内批准上市的能同时诊断HIV-1和HIV-2的试剂盒进行重复检测。结果判定按照试剂盒说明说明书。结果共收集到出现了HIV-2抗体指示性条带的样本378份,涉及病例363例。血清检测结果显示,326例(89.81%)HIV-1抗体阳性;18例(4.96%)HIV-2抗体阳性;12例(3.31%)HIV抗体阳性但不能分型;6例(1.65%)HIV抗体不确定;1例(0.28%)HIV-1/2抗体阴性。18例HIV-2抗体阳性样本来自湘潭市15例(83.33%)和长沙市3例(16.67%)。流行病学调查结果显示,男性12例(66.67%)、女性6例(33.33%),男女比2∶1;丧偶或离异6例(33.33%),在婚单阳8例(44.44%)、在婚双阳2例(11.11%)、婚姻状况不详2例(11.11%);首次检测平均年龄(56.94±12.52)岁,男性年龄跨度在33~76岁之间、女性年龄在44~66岁之间,男性年龄跨度比女性大;样本来源医院住院13例(72.22%)、监狱羁押和血站送检各2例(22.22%)、配偶筛查1例(5.56%);样本首次检测时间2005年、2009年、2013年、2014年、2018年、2020年各1例;2016年6例、2017年2例、2019年4例。截至2020年存活9人、死亡或者失联9人、已经开展抗病毒治疗3人。在能随访到的7例中,全部承认为异性性传播、6例否认有国外旅居史、1例否认有国外性接触史。结论HIV-2感染疫情在湖南省已经持续时间比较长,本地感染不是偶发个例,存在长期聚集性疫情传播的可能。这提示国家应加强对HIV-2的监测、检测、诊断治疗的研究,重视HIV-2传播的风险。Objective To understand the status of HIV-2 infection and the epidemiological characteristics of HIV-2 infected individuals in Hunan province.Methods The stock blood samples with HIV-2 indicative bands in the original records of 15 AIDS confirmation laboratories in Hunan province from 2003 to 2020 were collected.The samples were tested by Mikrogen GmbH(HIV 1+2)antibody comfirmatory kit(Germany).And meanwhile the epidemiological data of the first HIV test and the epidemiological follow-up records of the cases who could be contacted were collected.Results A total of 378 samples with HIV-2 indicative bands were collected,involving 363 individuals.Serological test result showed that 326 cases(89.81%)were HIV-1 antibody positive,18 cases(4.96%)were HIV-2 antibody positive,12 cases(3.31%)were HIV antibody positive but could not be typed,6 cases(1.65%)were HIV antibody uncertain and 1 case(0.28%)was negative for HIV-1/2 antibody.There were 15 cases from Xiangtan city and the other 3 cases from Changsha city among the 18 HIV-2 antibody positive individuals.The result of epidemiological investigation showed that there were 12 males(66.67%)and 6 females(33.33%),with a male-to-female ratio of 2∶1.The average age of the first detection was(56.94±12.52)years,in the males the age ranged from 33 to 76 years and in the females the age ranged from 44 to 66 years.The male age span was larger than that of the female.There were 10 married cases(55.56%)including one couple,6 divorced or widowed cases(33.33%),2 cases(11.11%)with unknown marital status.There were 13 cases from hospital monitoring(72.22%),2 cases each from prison detention and blood screening in volunteer donors(22.22%),and 1 case from spouse screening(5.56%).These samples were tested for the first time in 2005,2009,2013,2014,2018,and 2020,with 1 case each,6 cases in 2016,2 cases in 2017,and 4 cases in 2019.By the end of 2020,9 cases were alive and 9 cases were dead or missing.Three cases have accepted antiviral treatment.Of the 7 cases that could be followed up,all

关 键 词：人类免疫缺陷病毒-2 抗体 血清 流行病学 

分 类 号：R181.3[医药卫生—流行病学] R512.91[医药卫生—公共卫生与预防医学]