治疗复发或转移性宫颈癌的抗体偶联药物:Tisotumab Vedotin-tftv  

An antibody-drug conjugate in treating recurrent or metastatic cervical cancer:Tisotumab Vedotin-tftv

作　　者：黄佳 王浩[1] 钟薇[1] 陈玲[1] 伏箫燕 韩梦婷 陈岷[2,3] HUANG Jia;WANG Hao;ZHONG Wei;CHEN Ling;FU Xiaoyan;HAN Mengting;CHEN Min(Department of Pharmacy,Xindu District People’s Hospital of Chengdu,Chengdu,610500,Sichuan,China;Department of Pharmacy,Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital/Affiliated Hospital of University of Electronic Science and Technology,Chengdu,610072,Sichuan,China;Personalized Drug Therapy Key Laboratory of Sichuan Province,Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital/Affiliated Hospital of University of Electronic Science and Technology,Chengdu,610072,Sichuan,China)

机构地区：[1]成都市新都区人民医院药剂科,四川成都610500 [2]四川省医学科学院·四川省人民医院/电子科技大学附属医院药学部,四川成都610072 [3]四川省医学科学院·四川省人民医院/电子科技大学附属医院个体化药物治疗四川省重点实验室,四川成都610072

出　　处：《肿瘤药学》2022年第4期428-432,共5页Anti-Tumor Pharmacy

基　　金：中国药学会科技开发中心课题[CMEI2022KPYJ(JZYY)00726];国家重点研发计划(2020YFC2005506);四川省科技厅重点研发计划(2019YFS0514);个体化药物治疗四川省重点实验室开发课题(2021YB02);四川省干部保健科研课题(2021-238);四川省人民医院科研基金(2016LY04)。

摘　　要：Tisotumab Vedotin-tftv是美国食品药品监督管理局(FDA)批准的首款治疗宫颈癌的抗体偶联药物,也是全球首个获批靶向组织因子的抗体偶联药物,为复发或转移性宫颈癌患者提供了新的治疗选择。临床研究表明,Tisotumab Vedotin-tftv在复发或转移性宫颈癌患者中具有较好的抗癌活性,且安全性良好。本文就Tisotumab Vedotin-tftv的作用机制、药动学、临床研究及安全性进行概述。As the first antibody-drug conjugate(ADC) approved by the U.S.Food and Drug Administration(FDA) for the treatment of recurrent or metastatic cervical cancer,Tisotumab Vedotin-tftv is also a first-in-class ADC approved to target tissue factor,which provides a new treatment option for patients with recurrent or metastatic cervical cancer.Clinical studies have shown that Tsotumab Vedotin-tftv has good anticancer activity and safety in patients with recurrent or metastatic cervical cancer.In this paper,we mainly reviewed the mechanism,pharmacokinetics,clinical research and safety of Tisotumab Vedotin-tftv.

关 键 词：Tisotumab Vedotin-tftv 宫颈癌 抗体偶联药物 

分 类 号：R979.1[医药卫生—药品] R737.33[医药卫生—药学]