IFN-γ、IL-4及Tim-3与布鲁菌病病情、治疗效果的相关性研究  

Correlation Study of IFN-γ,IL-4 and Tim-3 with Brucellosis Condition and Therapeutic Effect

作　　者：李俊娜 韩晓亮 谢东文[1] 赵根成[1] LI Junna;HAN Xiaoliang;XIE Dongwen(Department of General Affairs,Anyang Fifth People’s Hospital,Anyang City,He’nan Province 455000)

机构地区：[1]河南省安阳市第五人民医院综合科,455000

出　　处：《医学理论与实践》2022年第18期3075-3077,3090,共4页The Journal of Medical Theory and Practice

摘　　要：目的:探讨干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)及可溶性T细胞免疫球蛋白黏蛋白3(Tim-3)与布鲁菌病病情、治疗效果的相关性。方法:选取2017年4月—2020年4月本院收治的布鲁菌病患者87例,并将其归为研究组。另选取同期于我院体检的健康志愿者75例设为对照组。对比研究组和对照组IFN-γ、IL-4及Tim-3表达水平及急性和慢性布鲁菌患者IFN-γ、IL-4、Tim-3表达水平;根据治疗效果将布鲁菌病患者分为有效组和无效组,对比两组IFN-γ、IL-4及Tim-3表达水平;采用多元Logistic回归分析影响布鲁菌病患者治疗效果的危险因素。结果:(1)研究组IFN-γ水平低于对照组,IL-4及Tim-3水平高于对照组(P<0.05);(2)急性组IFN-γ水平低于慢性组,IL-4及Tim-3水平高于慢性组(P<0.05);(3)87例布鲁菌病患者中,治疗有效67例(77.01%),治疗无效20例(22.99%);有效组IFN-γ水平高于无效组,IL-4及Tim-3水平低于无效组(P<0.05);(4)经Logistic回归模型分析显示,IFN-γ(异常降低)、IL-4(异常升高)、Tim-3(异常升高)是影响布鲁菌病患者治疗效果的独立危险因素(P<0.05)。结论:布鲁菌病患者IFN-γ呈低表达,IL-4及Tim-3呈高表达,其可能参与了布鲁菌病病情发生、发展的过程,检测上述因子水平有助于评估治疗效果。Objective:To discuss the correlations among interferon-γ(IFN-γ),interleukin-4(IL-4),T cell immunoglobulin and mucin-domain containing molecules family-3(Tim-3),brucellosis condition and treatment effect.Methods:87 patients with brucellosis admitted to this hospital from April 2017 to April 2020 were selected and classified as the study group.In addition,75 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group.The expression levels of IFN-γ,IL-4 and Tim-3 in the study group and the control group were compared.The expression levels of IFN-γ,IL-4 and Tim-3 in patients with acute and chronic Brucella were compared.According to the treatment effect,patients with brucellosis were divided into effective group and ineffective group,and the expression levels of IFN-γ,IL-4 and Tim-3 between the two groups were compared.Multivariate Logistic regression was used to analyze the risk factors that affected the treatment effect of patients with brucellosis.Results:(1)The level of IFN-γin the study group was lower than that of the control group,and the levels of IL-4 and Tim-3 were higher than those of the control group(P<0.05).(2)The IFN-γlevel of the acute group was lower than that of the chronic group,and the levels of IL-4 and Tim-3 were higher than those of the chronic group(P<0.05).(3)Among 87 patients with brucellosis,67 cases(77.01%)were effective in treatment,and 20 cases(22.99%)were ineffective in treatment.The IFN-γlevel of the effective group was higher than that of the ineffective group,and the levels of IL-4 and Tim-3 were lower than those of the ineffective group(P<0.05).(4)Analysis of Logistic regression model showed that IFN-γ(abnormal decrease),IL-4(abnormal increase),Tim-3(abnormal increase)were independent risk factors affecting the treatment effect of patients with brucellosis(P<0.05).Conclusion:IFN-γis low in patients with brucellosis,and IL-4 and Tim-3 are highly expressed,which may be involved in the occurrence and developm

关 键 词：布鲁菌病 IFN-Γ IL-4 TIM-3 治疗效果 

分 类 号：R516.7[医药卫生—内科学]