全程化药学服务对化疗所致恶心呕吐的影响  

Effects of Integrated Pharmaceutical Services on Chemotherapy-induced Nausea and Vomiting

作　　者：周佳琦 杨莉[2] 陈秀华[2] 缪璟榕 丰攀峰 陈霞[1] ZHOU Jia-qi;YANG Li;CHEN Xiu-hua;MIAO Jing-rong;FENG Pan-feng;CHEN Xia(Department of Pharmacy,the First People′s Hospital of Nantong,Nantong 226001,China;Department of Oncology,the First People′s Hospital of Nantong,Nantong 226001,China)

机构地区：[1]南通市第一人民医院药剂科,江苏南通226001 [2]南通市第一人民医院肿瘤科,江苏南通226001

出　　处：《海峡药学》2022年第8期121-124,共4页Strait Pharmaceutical Journal

基　　金：南通市卫生和计生委员会青年医学人才科研基金(QB2019002);江苏省药学会-恒瑞医院药学基金项目(H202047)。

摘　　要：目的分析全程化药学服务对结直肠癌患者化疗所致恶心呕吐(Chemotherapy-induced nausea and vomiting,CINV)的影响。方法选取肿瘤科2020年3月至8月收治的结直肠癌化疗患者并分为干预组和对照组,对照组仅按传统医疗流程为患者提供诊疗服务,干预组由临床药师实行全程化药学服务,包括入院风险评估、CINV监护、患者教育与随访、止吐方案调整以及建立分级管理标准,将两组CINV的发生情况以及患者满意度进行对比分析。结果干预后,急性期、延迟期以及总体CINV的完全缓解率由88.5%、54.0%和52.2%提高至89.0%、66.9%和65.4%,延迟期和总体CINV的差异具有统计学意义(P<0.05)。患者对住院照顾、止吐效果以及止吐教育的满意度由(4.10±0.756)分、(4.06±0.966)分和(3.98±0.866)分分别上升至(4.32±0.729)分、(4.29±0.790)分和(4.55±0.676)分(P<0.05)。结论全程化药学服务有效提高了肿瘤科结直肠癌患者CINV的控制率和患者的满意度。OBJECTIVE To analyze the effects of pharmaceutical services on chemotherapy-induced nausea and vomiting in patients with colorectal cancer(CRC).METHODS A prospective before-after study was conducted on CRC patients receiving chemotherapy from March 2020 to August 2020.The control group only received standard care whereas the intervention group was given additional pharmaceutical services,including evaluation of risk factors of nausea and vomiting,implementation of pharmaceutical care,patient education and counseling,follow-up,optimization of antiemetic medication and establishment of standards of hierarchical management.The incidence of CINV and patient satisfaction were compared between two groups.RESULTS After intervention,complete response in acute,delayed and overall periods rose from 88.5%,54.0%and 52.2%to 89.0%,66.9%and 65.4%,respectively.Significant difference was observed between two groups both in overall and delayed phases(P<0.05).Patient satisfaction scores of inpatient care,antiemetic effect and education rose from(4.10±0.756),(4.06±0.966)and(3.98±0.866)points to(4.32±0.729),(4.29±0.790)and(4.55±0.676)points,respectively(P<0.05).CONCLUSION Integrated pharmaceutical services effectively improved the control of CINV and patient satisfaction in colorectal cancer patients.

关 键 词：药学服务 化疗所致恶心呕吐 结直肠癌 

分 类 号：R969.4[医药卫生—药理学]