儿童传染性单核细胞增多症不同治疗方式效果比较  

Comparison of Different Treatment Methods for Infectious Mononucleosis in Children

作　　者：徐美莲[1] XU Mei-lian(Fujian Provincial Hospital,Provincial Clinical Medical College of Fujian Medical University,Fuzhou 350001,China)

机构地区：[1]福建省立医院,福建医科大学省立临床医学院,福建福州350001

出　　处：《海峡药学》2022年第8期129-132,共4页Strait Pharmaceutical Journal

摘　　要：目的观察不同治疗方式对儿科传染性单核细胞增多症的临床效果。方法回顾性分析2017年1月~2021年4月福建省立医院住院的传染性单核细胞增多症患儿78例,按照治疗方式分为对照组、激素组和抗病毒组,对照组为退热保肝等对症支持治疗,共24例;激素组在对症基础上同时给予注射用甲泼尼龙琥珀酸钠治疗,共26例;抗病毒组为对症基础上予更昔洛韦抗病毒治疗,共28例。比较三组临床症状改善时间、住院时间、不良反应发生情况。结果对照组与激素组相比,在临床症状改善时间、住院时间及不良反应发生率上无统计学差异。抗病毒组退热时间、住院时间及不良反应总发生率均高于对照组及激素组,差异有统计学意义(P<0.05)。结论IM治疗仍以对症支持治疗为主,对无严重并发症的患儿,激素治疗未发现明显受益。更昔洛韦抗病毒治疗在症状改善方面并未有积极作用,且延长了住院时间、增加了不良反应发生率。OBJECTIVE To observe the clinical effect of different treatment methods on Infectious Mononucleosis in children.METHODS A retrospective analysis was performed on 78 Infectious Mononucleosis children hospitalized in Fujian Provincial Hospital from January 2017 to April 2021.According to the treatment,they were divided into control group,glucocorticoid group and antiviral group.The control group was treated with symptomatic support,such as reducing fever and protecting liver function(n=24).The glucocorticoid group was treated with methylprednisolone on the basis of symptomatic support(n=26).The antiviral group was treated with ganciclovir based on symptomatic support(n=28).The improvement time of symptoms,length of hospital stay and incidence of adverse reactions were compared among the three groups.RESULTS There were no significant differences in symptom improvement time,length of hospital stay and incidence of adverse reactions between the control group and the glucocorticoid group.The antipyretic time,hospitalization time and total incidence of adverse reactions in the antiviral group were higher than those in the control group and glucocorticoid group,with statistical difference(P<0.05).CONCLUSION The treatment of Infectious Mononucleosis is still mainly symptomatic supportive treatment,and there is no significant benefit from glucocorticoid therapy for children without serious complications.Antiviral therapy with ganciclovir had no positive effect on symptom improvement,and prolonged hospital stay and increased the incidence of adverse reactions.

关 键 词：儿童 传染性单核细胞增多症 激素 更昔洛韦 

分 类 号：R969.4[医药卫生—药理学]