Copper-Catalyzed Asymmetric Formal Hydroaminomethylation of Alkenes with N,O-Acetals to Access Chiral β-Stereogenic Amines: Dual Functions of the Copper Catalyst  

作　　者：Yang’en You Quyet Van Pham Shaozhong Ge 

机构地区：[1]Department of Chemistry,National University of Singapore,Singapore 117543,Singapore

出　　处：《CCS Chemistry》2019年第4期455-463,共9页中国化学会会刊（英文）

基　　金：This work was supported by the Ministry of Education(MOE)of Singapore(no.R-143-000-A93-112).

摘　　要：Chiral amines are synthetically versatile intermedi-ates used for the preparation of a wide range of biologically active compounds and drugs.Compared with the well-developed synthesis ofα-stereogenic amines,the establishment of enantioselective protocols to accessβ-stereogenic amines are very limited.

关 键 词：ALKENE AMINOMETHYLATION asymmetric catalysis N O-acetal amine copper 

分 类 号：O62[理学—有机化学]