亚抗微生物剂量多西环素联合红蓝光治疗中重度痤疮的临床评价  

Clinical Evaluation of Subantimicrobial Dose of Doxycycline Combined with Red-blue Light in the Treatment of Moderate and Severe Acne

作　　者：周博 章海涛[1] ZHOU Bo;ZHANG Haitao(Department of Dermatology,Nantong Hospital of Traditional Chinese Medicine,Nantong 226001,Jiangsu,China)

机构地区：[1]南通市中医院皮肤科,江苏南通226001

出　　处：《中国美容医学》2022年第9期55-58,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨亚抗微生物剂量多西环素联合红蓝光治疗中重度痤疮的疗效及安全性。方法:于2020年1月-12月,选取笔者医院皮肤科收治的120例中重度痤疮患者,按照随机数字表法分为对照组与观察组,每组60例。对照组患者给予常规剂量(200 mg/d)多西环素胶囊联合红蓝光照射治疗,观察组患者给予亚抗微生物剂量(40 mg/d)多西环素胶囊联合红蓝光照射治疗,连续治疗8周。比较两组的临床效果,炎症及非炎症皮损数目,痤疮严重程度,血清炎性介质[白细胞介素-4(Interleukin-4,IL-4)、白细胞介素-8(Interleukin-8,IL-8)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)]水平及不良反应。结果:治疗后,观察组的总有效率明显高于对照组(91.67% vs 75.00%,P<0.05);观察组的炎症[(20.36±2.18)个vs(31.52±3.32)个]及非炎症[(12.70±2.60)个vs(20.16±3.38)个]皮损数目均明显少于对照组(P<0.05);观察组的血清IL-4[(53.18±12.75)ng/L vs (64.33±15.69)ng/L]、IL-8[(20.33±4.27)ng/L vs (25.80±6.45)ng/L]、TNF-α[(21.59±3.82)ng/L vs (26.63±5.24)ng/L]水平均明显低于对照组(P<0.05);观察组的不良反应发生率明显低于对照组(10.00% vs 21.67%,P<0.05)。结论:亚抗微生物剂量多西环素联合红蓝光治疗中重度痤疮的临床效果更加显著,能明显改善患者的痤疮症状及炎性反应,不良反应更少。Objective To investigate the efficacy and safety of submicrobial dose doxycycline combined with red and blue light in the treatment of moderate and severe acne.Methods From January to December 2020,a total of 120 patients with moderate and severe acne who was selected in the dermatology department of our hospital,and they were divided into control group and observation group according to random number table method,with 60 cases in each group.The patients were treated with conventional dose (200 mg/d) of doxycycline capsule combined with red-blue light in control group,and the patients were treated with subantimicrobial dose (40 mg/d) of doxycycline capsule combined with red-blue light in observation group,all the patients were continuously treated for 8 weeks.The clinical effect,inflammatory and non-inflammatory skin lesions,acne severity,serum levels of inflammatory mediators[interleukin-4 (IL-4),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]and adverse reactions were compared between the two groups.Results After treatment,the total effective rates in observation group was significantly higher than that in control group(91.67% vs 75.00%,P<0.05).The inflammatory skin lesions[(20.36±2.18)numbers vs (31.52±3.32)numbers]and non-inflammatory skin lesions[(12.70±2.60)numbers vs (20.16±3.38)numbers]in observation group was significantly less than that in control group(P<0.05).The serum levels of IL-4[(53.18±12.75)ng/L vs (64.33±15.69)ng/L],IL-8[(20.33±4.27)ng/L vs (25.80±6.45)ng/L],TNF-α[(21.59±3.82)ng/L vs (26.63±5.24)ng/L]in observation group was significantly lower than that in control group(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group (10.00% vs 21.67%,P<0.05).Conclusion The subantimicrobial dose of doxycycline combined with red-blue light in the treatment of moderate and severe acne had more significant clinical effects,which could significantly improve the acne symptoms and inflammatory response,with less adverse react

关 键 词：寻常痤疮 中重度 多西环素 亚抗微生物剂量 红蓝光 皮损 炎性介质 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]