MAP2 K5基因rs2241423多态性与儿童肥胖干预效果的关系  

Relationship between rs2241423 polymorphism of MAP2K5 gene and intervention effect of childhood obesity

作　　者：肖伍才 刘峥 陈敬 王辉[1] 宋洁云[2] 周双 高爱钰 张芳 王海俊[1] XIAO Wu-cai;LIU Zheng;CHEN Jing;WANG Hui;SONG Jie-yun;ZHOU Shuang;GAO Ai-yu;ZHANG Fang;WANG Hai-jun(Department of Maternal and Child Health,School of Public Health,Peking University,Beijing 100191,China;不详)

机构地区：[1]北京大学公共卫生学院妇幼卫生学系,北京100191 [2]北京大学儿童青少年卫生研究所 [3]北京市东城区中小学卫生保健所 [4]北京市门头沟区中小学卫生保健所

出　　处：《中国儿童保健杂志》2022年第9期952-955,980,共5页Chinese Journal of Child Health Care

基　　金：国家自然科学基金项目(81903343);国家重点研发计划项目(2016YFC1300204)。

摘　　要：目的探索MAP2 K5基因rs2241423多态性与儿童肥胖干预效果的关系,为未来开展基于遗传背景的个性化干预提供科学依据。方法在一项研究儿童肥胖干预效果的整群随机对照试验中,选取北京地区382名8~10岁儿童作为研究对象,收集唾液,检测MAP2 K5基因rs2241423多态性,并分析基因与干预对儿童肥胖的交互作用。结果MAP2 K5基因rs2241423多态性与干预措施对儿童BMI、BMI Z评分、腰臀比和体重等肥胖相关指标的改变存在交互作用(P_(交互)分别为0.034、0.007、0.039和0.036)。与对照组相比,干预组儿童在MAP2 K5基因rs2241423位点上每多携带一个G等位基因,BMI下降(-0.36kg/m^(2),95%CI:-0.69~-0.03kg/m^(2),P=0.034),BMI Z评分降低(-0.20,95%CI:-0.35~-0.06,P=0.007),腰臀比降低(-0.01,95%CI:-0.02~-0.001,P=0.039),体重减少(-0.84kg,95%CI:-1.63~-0.06kg,P=0.036)。结论在MAP2 K5基因rs2241423位点上携带G等位基因的儿童对干预更加敏感,接受干预后可在BMI及Z评分、腰臀比和体重指标上获得更多改善。Objective To explore the relationship between rs2241423polymorphism of MAP2 K5gene and the intervention effect of childhood obesity.Methods In a cluster randomized controlled trial to study the effect of intervention on childhood obesity in China,382children aged 8to 10in Beijing were selected as subjects.Saliva was collected to detect rs2241423polymorphism of MAP2 K5gene,and the interaction between gene and intervention on childhood obesity was analyzed.Results There was an interaction between rs2241423polymorphism of MAP2 K5gene and intervention on the changes of obesity-related indexes such as BMI,BMI Z-score,waist-hip ratio,and body weight in children(P_(forinteraction)=0.034,0.007,0.039,0.036).Compared with the control group,children in the intervention group carrying each additional G allele at MAP2 K5rs2241423locus,BMI decreased by-0.36kg/m^(2)(95%CI:-0.69to-0.03kg/m^(2),P=0.034),BMI Z-score decreased by-0.20(95%CI:-0.35to-0.06,P=0.007),waist-hip ratio decreased by-0.01(95%CI:-0.02to-0.001,P=0.039),and body weight decreased by-0.84kg(95%CI:-1.63 to-0.06,P=0.036),respectively.Conclusion Children who carried the G allele at rs2241423of MAP2 K5gene are more sensitive to intervention and showed more improvement in BMI and BMI Z-score,waist-hip ratio,and body weight after intervention.

关 键 词：儿童肥胖 基因 单核苷酸多态性 

分 类 号：R723.14[医药卫生—儿科]