海南省电力工人炎症因子水平及影响因素分析  

Analysis of current status and influencing factors of inflammatory factors among electrical workers in Hainan province

作　　者：韩金珂 李宾[2] 赵婵娟[1] 柳善河 唐荟瑜 燕贞 Han Jinke;Li Bin;Zhao Chanjuan;Liu Shanhe;Tang Huiyu;Yan Zhen(School of Public Health,Hainan Medical University,Haikou 571199,China)

机构地区：[1]海南医学院公共卫生学院,海口571199 [2]海南省疾病预防控制中心,海口570203

出　　处：《中华劳动卫生职业病杂志》2022年第8期586-591,共6页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金地区科学基金项目(81860583);海南省研究生创新科研课题(Hys2020-354)。

摘　　要：目的了解海南省电力工人血清炎症因子水平及其影响因素。方法于2020年9月,应用整群随机抽样抽取海南省2家发电厂509名一线电力工人为研究对象,采用问卷调查收集其人口学特征、生活行为方式以及工作相关情况等信息,并检测血清白细胞介素(IL)-6、IL-8及肿瘤坏死因子α(TNF-α)水平,用Mann-Whitney U检验或Kruskal-Wallis H检验进行组间炎症因子水平比较,有序多因素logistic回归进行影响因素分析。结果509名海南省电力工人平均年龄为(43.13±11.26)岁,平均工龄为(20.27±11.85)年,血清中IL-6、IL-8和TNF-α浓度中位数[M(Q1,Q3)]分别为2.78(1.77,4.00)、9.77(7.10,13.23)和8.18(6.18,11.26)pg/ml。与女性比较,性别为男性是电力工人IL-6水平升高的危险因素(OR=1.80,95%CI:1.08~3.00,P=0.024)。与51~60岁年龄段比较,21~31岁(OR=0.27,95%CI:0.18~0.42,P<0.001)、31~41岁(OR=0.27,95%CI:0.17~0.43,P<0.001)及41~51岁(OR=0.64,95%CI:0.41~0.99,P=0.043)均是IL-8水平升高的保护因素;与常白班作业的工人比较,倒班作业是电力工人IL-8水平升高的危险因素(OR=1.73,95%CI:1.21~2.48,P=0.003)。与女性比较,性别为男性是电力工人TNF-α水平升高的危险因素(OR=2.87,95%CI:1.70~4.86,P<0.001);与接触职业病危害因素数目为7种及以上的工人比较,接触1~3种(OR=0.53,95%CI:0.30~0.92,P=0.024)职业病危害因素是电力工人TNF-α水平升高的保护因素。结论海南省电力工人血清IL-6、IL-8和TNF-α水平与性别、年龄、工作制度和职业环境有关。Objective To analyze the level and influence factors of inflammatory factors among electrical workers in Hainan Province.Methods A total of 509 electrical workers were selected as the research subjects with random cluster sampling in September 2020.Basic information was collected by questionnaire,the serum IL-6,IL-8 and TNF-αlevels of the subjects were detected by Luminex.Mann-Whitney U test and Kruskal-wallis H test were used for univariate analysis.Ordinal logistic regression analysis was used for potential influencing factors of the level of inflammatory factors.Results The median concentrations of IL-6,IL-8 and TNF-αin serum were 2.78,9.77 and 8.18 pg/ml.Compared with women,male was a risk factor for the increase of IL-6 levels(OR=1.80,95%CI:1.08~3.00,P=0.024).Compared with 51-60 years old,21-31 years old(OR=0.27,95%CI:0.18~0.42,P<0.001),31-41 years old(OR=0.27,95%CI:0.17~0.43,P<0.001)and 41-51 years old(OR=0.64,95%CI:0.41~0.99,P=0.043)were protective factors for the increase of IL-8 level.Compared with day shift workers,shift work was a risk factor for the increase of IL-8 level(OR=1.73,95%CI:1.21~2.48,P=0.003).Compared with women,male was a risk factor for the increase of TNF-αlevels(OR=2.87,95%CI:1.70~4.86,P<0.001).Compared with workers who exposed to 7 or more occupational hazard factors,exposed to 1~3(OR=0.53,95%CI:0.30~0.92,P=0.024)occupational hazard factors were protective factors for the increase of TNF-αlevels.Conclusion The level of inflammatory factors was related to sex,age,work system and occupational environment,which can provide basic data for follow-up research on occupational population.

关 键 词：工人 炎症趋化因子类 白细胞介素 肿瘤坏死因子 炎症因子 影响因素 电力工人 

分 类 号：R135[医药卫生—劳动卫生]