尿中6种苯系物测定的吹扫捕集-气相色谱质谱法  

Determination of 6 BTEXs in urine by purge and trap with gas chromatography-mass spectrometry

作　　者：赖璟琦[1] 赖少阳[1] 叶小莉 王超[2] 叶敏[1] Lai Jingqi;Lai Shaoyang;Ye Xiaoli;Wang Chao;Ye Min(Laboratory of Physical and Chemical,Shenzhen Luohu District Center for Disease Control and Prevention,Shenzhen 518020,China;Chemical Analysis&Physical Testing Institute,Shenzhen Center for Disease Control and Prevention,Shenzhen 518000,China)

机构地区：[1]深圳市罗湖区疾病预防控制中心理化检验科,深圳518020 [2]深圳市疾病预防控制中心理化检测所,深圳518000

出　　处：《中华劳动卫生职业病杂志》2022年第8期619-622,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：2019年罗湖区软科学研究计划项目(LX20190501)。

摘　　要：目的建立尿中6种苯系物的吹扫捕集-气相色谱/质谱法。方法尿样原液直接在吹扫捕集瓶内进行吹扫后进样,气相色谱柱分离,采用保留时间锁定定性、选择离子扫描模式(SIM)检测分析。结果尿中6种苯系物在各浓度范围内线性范围良好,相关系数0.9974~0.9989,方法检出限0.010~0.036μg/L,方法精密度1.9%~4.7%,样品加标回收率93.1%~101.9%。结论该方法直接对尿样进行吹扫,降低仪器堵塞和污染风险,线性范围宽,灵敏度高,回收率高,适用于低浓度职业接触或非暴露人群尿中6种苯系物的测定。Objective To establish a method for detection of 6 BTEXs in urine by Purge and Trap-Gas Chromatography-Mass Spectrometry.Methods The urine sample need not be diluted,but directly purge and trap in the bottle,separated by gas chromatography column,then simultaneously analyzed by retention time locking(RTL)method and selective ion scanning mode(SIM).Results The linear range of 6 BTEXs in urine was good,the correlation coefficient was between 0.9974 and 0.9989.The minimum quantification limits was 0.010-0.036μg/L.The precision was 1.9%-4.7%,and the recovery was 93.1%-101.9%.Conclusion The method has the advantages of wide linear range,high sensitivity and recovery.It is suitable for the determination of 6 BTEXs in urine of low level occupational-exposed or non-exposed population.

关 键 词：气相色谱/质谱法 吹扫捕集 尿 苯系物 

分 类 号：R446.12[医药卫生—诊断学]