血清MIF在冠心病心绞痛患者中的变化及与心肌损伤关系分析  

Changes of serum MIF in patients with coronary heart disease and angina pectoris and its relationship with myocardial injury

作　　者：金晶晶 于艳洁 张庆 JIN Jing-jing;YU Yan-jie;ZHANG Qing(Emergency department of Zhengzhou Central Hospital Affiliated to Zhengzhou University,Henan Zhengzhou 450000)

机构地区：[1]郑州大学附属郑州中心医院急诊科,河南郑州450000

出　　处：《医学检验与临床》2022年第8期4-7,共4页Medical Laboratory Science and Clinics

摘　　要：目的:探究血清巨噬细胞移动抑制因子(MIF)在冠心病心绞痛患者中的变化及与心肌损伤的关系分析。方法:选取郑州大学附属郑州中心医院2019年5月~2021年5月接收的78例冠心病心绞痛患者作为研究对象,其中32例稳定型心绞痛(SAP)患者为SAP组,46例不稳定型心绞痛(UAP)患者为UAP组,另选取40例体检检查结果正常者作为健康组。观察SAP组、UAP组及健康组3组MIF水平情况。将78例冠心病心绞痛患者依据是否发生心肌损伤分为两组,即心肌损伤组(35例)与非心肌损伤组(43例),观察心肌损伤组与非心肌损伤组两组MIF及心肌损伤标志物水平情况,采用Pearson相关性分析探究MIF水平与心肌损伤的相关性。结果:UAP组MIF水平高于SAP组及健康组(P<0.05),SAP组MIF水平高于健康组(P<0.05)。心肌损伤组MIF、肌酸激酶同工酶(CK-MB)、肌钙蛋白I(CTnI)水平均高于非心肌损伤组(P<0.05)。经Pearson分析结果显示,MIF水平与CK-MB、CTnI水平存在正相关(r=0.415、0.566,P<0.05)。结论:稳定型与不稳定型心绞痛患者MIF表达水平有差异,提示MIF可能与患者冠状动脉粥样硬化斑块不稳定性相关,且MIF与患者心肌损伤存在密切联系,可为临床评估冠心病心绞痛病情进展提供相应依据。Objective:To explore the changes of serum macrophage migration inhibitory factor(MIF)in patients with coronary heart disease and angina pectoris and its relationship with myocardial injury.Methods:A total of 78 patients with coronary heart disease and angina pectoris received from Zhengzhou Central Hospital Affiliated to Zhengzhou University,Sichuan Province from May 2019 to May 2021 were selected as the research subjects,of which 32 patients with stable angina pectoris(SAP)belonged to the SAP group and 46 patients with unstable angina pectoris.The patients with angina pectoris(UAP)belonged to the UAP group,and another 40 patients with normal physical examination results were selected as the healthy group.The MIF levels of SAP group,UAP group and healthy group were observed.Seventy-eight patients with coronary heart disease and angina pectoris were divided into two groups according to whether myocardial injury occurred,namely myocardial injury group(35 cases)and non-myocardial injury group(43 cases).Marker levels,Pearson correlation analysis was used to explore the correlation between MIF levels and myocardial injury.Results:The MIF level of UAP group was higher than that of SAP group and healthy group(P<0.05),and the MIF level of SAP group was higher than that of healthy group(P<0.05).The levels of MIF,creatine kinase isoenzyme(CK-MB)and troponin I(CTnI)in the myocardial injury group were higher than those in the non-myocardial injury group(P<0.05).The results of Pearson analysis showed that MIF levels were positively correlated with CK-MB and CTnI levels(r=0.415,0.566,P<0.05).Conclusion:There are differences in the expression levels of MIF in patients with stable and unstable angina pectoris,suggesting that MIF may be related to the instability of coronary atherosclerotic plaques,and MIF is closely related to myocardial injury in patients,which can be used for clinical evaluation of coronary heart disease angina pectoris.Provide corresponding basis for disease progression.

关 键 词：血清巨噬细胞移动抑制因子 冠心病 不稳定型心绞痛 稳定型心绞痛 心肌损伤 

分 类 号：R541.4[医药卫生—心血管疾病] R542.2[医药卫生—内科学]