阿帕替尼的合成路线图解  

Graphical Synthetic Routes of Apatinib

作　　者：唐铭宏 孟鑫池 崔飞雪 杨尚杰 石琪 陈石 姜春风 TANG Ming-hong;MENG Xin-chi;CUI Fei-xue;YANG Shang-jie;SHI Qi;Chen Shi;JIANG Chun-feng(School of Biomedicine and Chemical Engineering,Liaoning Institute of Science and Technology,Benxi Liaoning 117004,China;He Eye Specialist Hospital,Shenyang Liaoning 110034,China)

机构地区：[1]辽宁科技学院药化学院,辽宁本溪117004 [2]沈阳何氏眼科医院,辽宁沈阳110034

出　　处：《辽宁科技学院学报》2022年第4期40-42,58,共4页Journal of Liaoning Institute of Science and Technology

基　　金：辽宁省教育厅科学研究经费项目(L2020lkyqn-05(202007171));大学生创新项目(202111430053).

摘　　要：阿帕替尼(商品名:艾坦)是由我国恒瑞医药自主研发的全球第一个治疗晚期胃癌的小分子靶向抗肿瘤药物,2014年获批上市。本文对阿帕替尼的合成路线进行了综述与分析,以期望为工业化生产提供新的思路。Apatinib is the world's first small-molecule targeted anti-tumor drug for advanced gastric cancer independently developed by China Hengrui Pharmaceutical Co.,LTD.The drug was approved for marketing in 2014.In this paper,the synthetic routes of apatinib was reviewed and analyzed in order to provide new guidance for industrial production.

关 键 词：阿帕替尼 小分子靶向抗肿瘤药物 合成路线 图解 

分 类 号：R979.19[医药卫生—药品]