电针技术电化疗肌肉内血管瘤电传导机制建模与分析  

Modeling and analysis of electrical signal transduction mechanism in electroacupuncture-based electrochemotherapy of intramuscular hemangioma

作　　者：张双 徐晶 余远昱 王久江 旷江明 杨济宁 张涛[2,3] ZHANG Shuang;XU Jing;YU Yuanyu;WANG Jiujiang;KUANG Jiangming;YANG Jining;ZHANG Tao(School of Artificial Intelligence,Neijiang Normal University,Neijiang 641100,China;School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 611731,China;High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province,University of Electronic Science and Technology of China,Chengdu 611731,China;Smart Medical Engineering Applications Laboratory,Neijiang Normal University,Neijiang 641100,China;NJNM-OMNISKY Smart Medical Engineering Applications Joint Laboratory,Neijiang Normal University,Neijiang 641100,China)

机构地区：[1]内江师范学院人工智能学院,四川内江641100 [2]电子科技大学生命科学与技术学院,四川成都611731 [3]电子科技大学高场磁共振脑成像四川省重点实验室,四川成都611731 [4]内江师范学院智慧医疗工程应用实验室,四川内江641100 [5]内江师范学院内师-容天智慧医疗工程应用联合实验室,四川内江641100

出　　处：《中国医学物理学杂志》2022年第9期1145-1150,共6页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(U19A2082);四川省科技创新创业苗子工程重点项目(2022JDRC0134);四川省重点研发计划(重大专项)项目(2021YFSC0040);四川省国际港澳台科技创新合作重点研发项目(2022YFH0110);中国博士后科学基金面上项目(2020M683294);成都医学院四川应用心理学研究中心资助项目(CSXL-21103);内江师范学院科研团队项目(17TD03,2021TD02)。

摘　　要：目的:基于电针的电化学治疗方法,通过向电针中注入直流电信号,利用电流弥散来实现对肿瘤细胞的电解、电渗作用,实现癌症的定向精准治疗,为了研究电针信号在手臂肌肉内的信号传导情况,为精准治疗提供理论依据。方法:结合人体解剖学与组织结构学,在COMSOL Multiphysics 5.5有限元仿真软件中,利用圆台、圆柱、椭球为几何实体,建立电针电化疗数值仿真有限元模型,并在频域环境下,通过注入载波信号为100 kHz、±20 mA的直流电信号,以此分析信号在手臂中的传播机制。结果:感应电势、电流密度分布主要集中在裸露电针头部周围,电势衰减约为11 dB/cm,距离较远时几乎检测不到通过电针注入的电流信号。结论:在精准电化疗肿瘤治疗系统中,传导距离越远,信号衰减越大,距离较远时,检测端几乎检测不到通过电针注入的电流信号,充分说明电针治疗几乎不会对离它具有一定距离(距离大小根据电针大小与注入电流情况而改变)的设备产生影响。Objective In the electrochemical therapy based on electroacupuncture,the electrolysis and electroosmosis of tumor cells are realized by injecting direct electrical signal into electroacupuncture to generate current diffusion,so as to achieve the targeted and precision treatment of cancer.The signal transmission of electroacupuncture signal in arm muscle is analyzed in the study for providing theoretical basis for precision treatment.Methods By combining human anatomy and histological structure,the numerical simulation finite element model of electroacupuncture-based electrochemotherapy was established in COMSOL Multiphysics 5.5 software,with the round table,cylinder and ellipsoid as geometric entities.The electrical signal transduction mechanism in the arm was analyzed by injecting the direct electrical signal of±20 mA with carrier signal of100 kHz in the frequency domain environment.Results The distributions of inductive potential and current density were mainly concentrated around the head of bare electroacupuncture,and the potential attenuation was about 11 dB/cm.When the distance became larger,the current signal injected through electroacupuncture could hardly be detected.Conclusion In the electrochemotherapy for precision treatment of tumor,the farther the conduction distance is,the greater the signal attenuation is.When the distance is large enough,the current signal injected through electroacupuncture can hardly be detected at the detection end,which shows clearly that electroacupuncture treatment will hardly affect the equipment located at a certain distance from it(the distance depends on the electroacupuncture size and the injection current).

关 键 词：电针 电化疗 有限元模型 肌肉内血管瘤 电传导机制 

分 类 号：R318[医药卫生—生物医学工程] Q42[医药卫生—基础医学]