静坐时间与心脑血管病死亡关系的前瞻性队列研究  

Association of sedentary time with cardiocerebral deaths:a prospective cohort study

作　　者：周伟[1] 祝玲娟[1] 王涛 鲍慧慧[1,2] 程晓曙[1,2] ZHOU Wei;ZHU Ling-juan;WANG Tao;BAO Hui-hui;CHENG Xiao-shu(Center for Prevention and Treatment of Cardiovascular Diseases,the Second Affiliated Hospital of Nanchang University,Nanchang,Jiangri 330006,China;Department of Cardiology,the Second Affiliated Hospital of Nanchang University,Nanchang,Jiangri 330006,China)

机构地区：[1]南昌大学第二附属医院心血管病防治中心,江西南昌330006 [2]南昌大学第二附属医院心内科,江西南昌330006

出　　处：《中华高血压杂志》2022年第8期761-766,共6页Chinese Journal of Hypertension

基　　金：“十二五”国家科技支撑计划项目(2011BAI11B01)。

摘　　要：目的探讨静坐时间对心脑血管病死亡的影响。方法采用前瞻性队列研究方法,选取2013-2014年“中国重要心血管病患病率调查及关键技术研究”在江西地区调查的年龄≥35岁社区居民12608人进入随访队列。基线问卷调查获得静坐时间,通过电话随访、乡镇卫生院公共卫生科和村医信息报告及江西省疾病预防控制中心死亡监测系统获得死亡事件。应用Cox比例风险模型评估死亡风险。结果共纳入研究对象11744人进行分析,平均随访(5.4±0.9)年(63297.8人年),随访期间发生死亡事件796例,其中心脑血管病死亡事件373例。静坐时间<6、6~8和>8 h/d组心脑血管病死亡事件发生率分别为2.9%(273/9645)、3.9%(63/1595)和5.4%(37/684),组间差异有统计学意义(χ^(2)=13.57,P<0.01)。Kaplan-Meier曲线显示,三组间心脑血管病累积死亡风险差异有统计学意义(Log-Rank χ^(2)=17.27,P<0.01)。Cox回归分析显示,调整混杂因素后,高龄、体质量指数(BMI)增加、男性、农村、高血压、失业及静坐时间长是发生心脑血管病死亡事件的危险因素。与静坐时间<6 h/d人群相比,静坐时间>8 h/d人群发生心脑血管病死亡的风险较高,HR(95%CI)为1.683(1.186~2.388)。结论静坐时间长是心脑血管病死亡的独立危险因素。Objective To explore the association of sedentary time with cardiocerebral deaths.Methods A total of 12608 community residents aged 35 years or above in Jiangxi Province who took part in"the study on prevalence of major cardiovascular diseases and key techniques in China"during 2013 and 2014 were enrolled in this prospective,observational cohort study.Sedentary time was obtained through baseline questionnaire,and all death events were collected by telephone follow-up,information reported from the departments of public health in township health centers and village doctors,and death surveillance system of Jiangxi Center for Disease Control and Prevention.Cox proportional hazard regression model was used to evaluate the association of sedentary time with cardiocerebral deaths.Results A total of 11744 participants were included in final analysis.During an average 5.4 years of follow up(63297.8 person-years),796 all-cause deaths occured,including 373 cardiocerebral deaths.The difference of cardiocerebral death rate were statistically significant in three groups of<6 h/d(2.9%),6-8 h/d(3.9%)and>8 h/d(5.4%),respectively(χ^(2)=13.57,P<0.01).Kaplan-Meier curve showed that there was a significant difference in the cumulative mortality among three groups(Log-Rank χ^(2)=17.27,P<0.01).Cox regression analysis showed that after adjusting for relevant confounding factors,older age,high body mass index(BMI),male,rural residents,unemployment and long sedentary time were risk factors for cardiocerebral deaths.Compared with the<6 h/d group,the risk of cardiocerebral deaths increased by 68.3%(HR=1.683,95%CI 1.186-2.388)for participants with sedentary time of>8 h/d.Conclusion Long sedentary time independently increases the risk of cardiocerebral deaths.

关 键 词：静坐时间 心脑血管病 死亡 前瞻性研究 

分 类 号：R54[医药卫生—心血管疾病] R743[医药卫生—内科学]