新生儿高促甲状腺素血症围产期危险因素分析  

Perinatal Risk Factors of Neonatal Hyperthyrotropinemia

作　　者：张彩营[1] 奎正平 王琼[2] 赵小龙 侯晓梅[3] 齐志业[1,2] ZHANG Caiying;KUI Zhengping;WANG Qiong;ZHAO Xiaolong;HOU Xiaomei;QI Zhiye(Dept.of Pediatrics;Neonatal Screening Center,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China;Dept.of Obstetrics,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一附属医院儿科,云南昆明650032 [2]昆明医科大学第一附属医院新生儿遗传代谢病筛查中心,云南昆明650032 [3]昆明医科大学第一附属医院产科,云南昆明650032

出　　处：《昆明医科大学学报》2022年第9期48-52,共5页Journal of Kunming Medical University

基　　金：云南省科技厅科技计划基金资助项目(202101AY070001-099)。

摘　　要：目的探讨围产相关因素与新生儿高促甲状腺素血症(hyperthyrotropinemia,HT)的关系。方法选择2016年1月至2020年12月在昆明医科大学第一附属医院促甲状腺素筛查阳性新生儿作为研究对象,其中诊断为HT的新生儿为病例组,甲状腺功能检查正常新生儿为对照组。采用单因素和多因素Logistic回归模型分析新生儿HT的相关危险因素。结果单因素分析显示,病例组高龄产妇和早产的比例高于对照组(P<0.05)。多因素Logistic回归模型显示,高龄产妇(OR=2.320,95%CI:1.099~4.897)和早产(OR=2.960,95%CI:1.354~6.473)增加新生儿HT的发生风险。结论高龄产妇和早产是新生儿HT的危险因素。应加强孕期保健,减少新生儿HT的危险因素,降低新生儿HT的发病率。Objective To investigate the association between neonatal Hyperthyrotropinemia(HT)and perinatal risk factors.Methods A case-control study was conducted among 109 newborns with HT(case group)and 127 newborns without HT(control group)in the First Affiliated Hospital of Kunming Medical University from Jan.2016 to Dec.2020.Univariate and multivariate logistic regression analysis was conducted to identify the perinatal risk factors to neonatal HT.Results Univariate analysis indicated that the incidence of advanced maternal age and preterm delivery in the case group were significantly higher than those in the control group.The results of multivariate logistic regression analysis showed that advanced maternal age(OR=2.320,95%CI:1.099~4.897)and preterm delivery(OR=2.960,95%CI:1.354~6.473)increased the risk of neonatal HT.Conclusion Advanced maternal age and preterm delivery were the independent perinatal risk factors for neonatal HT.Efforts should be made to provide high quality pregnancy care,decrease the perinatal risk factors of neonatal HT,and to reduce the incidence of neonatal HT.

关 键 词：围产期 新生儿 高促甲状腺素血症 危险因素 病例对照研究 

分 类 号：R722.1[医药卫生—儿科]