人类胎盘的葡萄糖转运机制及GDM对胎盘葡萄糖转运的影响  

Glucose Transport in Human Placenta and the Effect of GDM on Placental Glucose Transport

作　　者：何银东 张峻[1] 黄桦[1] 柳汝明[1] 王茜[1] HE Yindong;ZHANG Jun;HUANG Hua;LIU Ruming;WANG Xi(Dept.of Clinical Medicine,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一附属医院临床药学科,云南昆明650032

出　　处：《昆明医科大学学报》2022年第9期160-165,共6页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(82160297,H0416);云南省高层次卫生计生技术人才培养专项基金资助项目(L-201614,H-2018077,H-201705,H-2018081);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2019FE001(-200),2018FE001(-167),202001AY070001-045,2018FE001(-310)]。

摘　　要：胎盘是将母体葡萄糖转运至子体的重要器官,正常的胎盘结构和功能为胎儿从母体有效摄取葡萄糖提供保障。胎盘上葡萄糖转运主要依赖于胎盘上的葡萄糖转运体(glucose transporters,GLUTs)。此外,胎盘自身对葡萄糖代谢也会影响经胎盘的葡萄糖转运。妊娠期糖尿病(gestational diabetes mellitus,GDM)是一种常见的妊娠期并发症。GDM患者胎盘上葡萄糖转体运功能的异常,可能是造成其子代产生不良结局的原因之一。就正常胎盘上的葡萄糖转运进行论述,并且探讨GDM患者胎盘上葡萄糖转运的改变及可能的分子机制。Placenta plays an important role in the process of glucose transfer from maternal to fetus.The normal structure and function of the placenta guarantee the fetus to take up glucose effectively from maternal side over the gestation.Glucose transplacental transfer mainly depends on the glucose transporters(GLUTs).And the placenta and other factors such as placental glucose metabolic activity could also affect the glucose transplacental transfer.Gestational diabetes mellitus(GDM)is a main complication of pregnancy.Fetal adverse outcomes from GDM patients may be caused by the abnormality of glucose transport in the placenta.This review aims to discuss the glucose transplacental transfer on the normal placenta and summarize some changes and molecular mechanism that have been reported about glucose transplacental transfer in the GDM.

关 键 词：胎盘 葡萄糖转运 葡萄糖转运体 妊娠期糖尿病 

分 类 号：R713.1[医药卫生—妇产科学]