金龙胆草的体内及体外抗菌作用  

The Antibacterial Action of Conyza Blinii Lévl in Vivo and Vitro

作　　者：高垚 郭向群 潘立文 飞志红 GAO Yao;GUO Xiang-Qun;PAN Li-Wen;FEI Zhi-Hong(Department of pharmacy,Chuxiong Medical College,Chuxiong 675005,China;School of Basic Medicine,Yunnan University of Traditional Chinese Medicine,Kunming 650500,China)

机构地区：[1]楚雄医药高等专科学校药学系,云南楚雄675005 [2]云南中医药大学基础医学院,昆明650500

出　　处：《中国药物经济学》2022年第8期111-114,共4页China Journal of Pharmaceutical Economics

基　　金：云南省教育厅科学研究基金项目(2018JS635)。

摘　　要：目的 通过金龙胆草水煎液体内及体外抗菌作用实验,研究金龙胆草水煎液体内及体外抗菌活性。方法 用金龙胆草水煎液对金黄色葡萄球菌、枯草杆菌、大肠杆菌3株细菌进行体外抑菌作用研究,通过灌胃给药,观察金黄色葡萄球菌感染小鼠皮肤脓肿模型的脓肿消退程度,观察其体内抗菌作用。结果 金龙胆草水煎液(0.5 g/ml)在体外对金黄色葡萄球菌高度敏感,抑菌圈直径为(28.37±4.92)mm,对枯草杆菌中度敏感,抑菌圈直径为(13.89±0.71)mm,对大肠杆菌不敏感,抑菌圈直径为0;其对感染金黄色葡萄球菌小鼠皮肤脓肿有明显消退作用,效果优于头孢克洛。结论 金龙胆草对体内、体外金黄色葡萄球菌感染有明显抑制作用。Objective To study the antibacterial activity in vivo and vitro of Conyza blinii Lévl water decoction through the experiment of antibacterial action of Conyza blinii Lévl water decoction in vivo and vitro. Methods Conyza blinii Lévl water decoction was used to study the antibacterial action in vitro of three strains of bacteria including staphylococcus aureus, bacillus subtilis and escherichia coli. Through intragastric administration, the degree of abscess subsidence in the skin abscess model of mice infected with staphylococcus aureus was observed, as well as its antibacterial action in vivo. Results Conyza blinii Lévl water decoction(0.5 g/ml) was highly sensitive to staphylococcus aureus in vitro, the diameter of inhibition zone was(28.37±4.92) mm,and it was moderately sensitive to bacillus subtilis, the diameter of inhibition zone was(13.89±0.71) mm. It was not sensitive to escherichia coli, the diameter of inhibition zone was 0. Intragastric administration was used to treat the skin infection model of staphylococcus aureus in mice, and it was found that oral administration of its water decoction could help the subsidence of skin abscess infected by staphylococcus aureus in mice, and its effect was better than that of cefaclor. Conclusion Conyza blinii Lévl can inhibit staphylococcus aureus infection in vivo and vitro.

关 键 词：金龙胆草 体外抗菌 体内抗菌 金黄色葡萄球菌 

分 类 号：R285[医药卫生—中药学]