纳西东巴医学中的因“秽”致病理论与“除秽”防病机理的数据整理研究  

Data Collation and Research on the Theory of Disease Caused by“filth”and the Disease Prevention Mechanism of“Dispel Filth”in Naxi Dongba Medicine

作　　者：崔建枝 王均琪 和志华 和学承 和成凤 彭识 赵元孙 刘建勤 李志勇 CUI Jianzhi;WANG Junqi;HE Zhihua;HE Xuecheng;HE Chengfeng;PENG Shi;ZHAO Yuansun;LIU Jianqin;LI Zhiyong(BasicMedical Cllege,Shanxi University of Chinese Medicine,Jinzhong 030619,China;Lijiang Medical Association of Minorities,Yunnan Province,Ljiang 674100,China;School of Pharmacy,Minzu University of China,Bejing 100081,China;Lijiang Agricultural Science Institute,Yunnan Province,Lijiang 674100,China;Intangible center,Yulong county,Yunnan Province,Yulong 674100,China;Yunnan Synergistic Innovation Center for the Exploitation and Research of New Resources of Traditional Chinese Medicine,Kunming 650051,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]山西中医药大学基础医学院,山西晋中030619 [2]云南省丽江市民族医药协会,云南丽江674100 [3]中央民族大学药学院,北京100081 [4]云南省丽江市农业科学研究所,云南丽江674100 [5]云南省玉龙县非遗中心,云南玉龙674100 [6]云南省中药新资源开发研究协同创新中心,云南昆明650051 [7]中国中医科学院中药研究所,北京100700

出　　处：《中国民族民间医药》2022年第17期1-6,共6页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：国家中医药管理局全国中药资源普查项目(GZY-KJS-2018-004)。

摘　　要：目的:梳理纳西传统医学中的“秽”及“除秽”的方法,采用网络药理学方法探讨纳西族通过除秽预防疾病的可能的作用机制。方法:借助旨在促进对环境暴露如何影响人类健康的理解的CTD数据库,获取纳西族除秽主要植物的挥发性成分相应的靶点,通过STRING数据库、Cytoscape软件、DAVID数据库分别构建靶点PPI网络、提取核心PPI网络及关键靶点、对关键靶点进行富集分析。结果:获得挥发性成分关键靶点164个,通路涉及乙型肝炎、病毒致癌、甲型流感、HTLV-I感染、Fox O信号通路、HIF-1信号通路、TNF信号通路等。结论:除秽实质上是消除细菌病毒、保持环境卫生的活动。除秽植物可能通过多种挥发性成分作用于多靶点抑制病毒、调节炎症反应,发挥消毒杀菌、预防疫病的作用。Objective The purpose of this paper is to sort out the filth and the methods of dispeling filth in traditional Naxi medicine,and to explore the possible mechanism of Naxi peoples prevention of diseases by dispeling filth by means of network pharmacology. Methods With the help of CTD database,which aims to promote the understanding of how environmental exposure affects human health,the corresponding targets of volatile components of the main plants of Naxi nationality were obtained. The target PPI network is constructed by STRING database,the core PPI network and key targets are extracted by Cytoscape software,and the key targets are enriched and analyzed by DAVID database. Results 164 key targets of volatile components were obtained,and pathways mainly included hepatitis B,viral carcinogenesis,influenza A,HTLV-I infection,Fox O signal pathway,HIF-1 signal pathway,TNF signal pathway,etc. Conclusion Dispeling filth is essentially an activity to eliminate bacteria and viruses and maintain environmental hygiene. The various volatile components of decontaminating plants may play an important role in disinfection and sterilization and preventing epidemic disease by acting on multiple targets to inhibit virus and regulate inflammatory response.

关 键 词：纳西族 除秽 疫病 网络药理学 

分 类 号：R285[医药卫生—中药学]