厚朴酚与和厚朴酚对脑损伤的保护作用及其机制的研究进展  

Research Progress in the Protective Effect of Magnolol and Honokiol on Brain Injury and Their Mechanisms

作　　者：张明发[1] 沈雅琴[1] ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd.,Shanghai 201204,China)

机构地区：[1]上海美优制药有限公司,上海201204

出　　处：《抗感染药学》2022年第5期621-626,共6页Anti-infection Pharmacy

基　　金：国家自然科学基金资助项目(编号:39370838)。

摘　　要：整体实验结果显示,厚朴酚与和厚朴酚对缺氧、缺血、缺血再灌注、出血、高热中暑和脓毒症引起的脑损伤有保护作用。离体实验也证实,厚朴酚与和厚朴酚能对抗化学性缺氧、葡萄糖缺乏、缺血再灌注、高热,以及过氧化氢(HO)、兴奋性神经递质N-甲基-D-门冬氨酸(NMDA)和谷氨酸、三甲基锡引起的神经细胞损伤。这都提示,厚朴酚与和厚朴酚可能是通过直接清除氧自由基和提高机体的抗氧化酶活性而间接清除氧自由基,以及阻滞磷脂酰肌醇3-激酶(PI3K)-蛋白激酶B(Akt)、胞外信号调节激酶(ERK)-促分裂素原活化蛋白激酶(MAPK)和Toll样受体(TLR)/MAPK/核因子κB(NF-κB)等信号通路而抑制炎性细胞因子表达,从而产生抗氧化和抗炎作用,进而发挥脑保护作用。此外,厚朴酚与和厚朴酚还可通过促进抑制性神经递质γ-氨基丁酸的生物合成和增强γ-氨基丁酸的受体结合能力,从而对抗兴奋性神经递质对神经细胞的伤害。该文综述了厚朴酚与和厚朴酚对脑损伤的保护作用及其机制,并对其研究进展做了分析。The overall test results showed that magnolol and honokiol had protective effects on brain injury caused by hypoxia,ischemia,ischemia-reperfusion,hemorrhage,febrile heatstroke and sepsis.The in vitro experiments also confirmed that magnolol and honokiol could resist the injury of nerve cells caused by chemical hypoxia,glucose deficiency,ischemia-reperfusion,hyperthermia,hydrogen peroxide(HO),excitatory neurotransmitter N-methyl-D-aspartate(NMDA)and glutamic acid,and trimethyltin.This suggests that magnolol and honokiol may inhibit the expression of inflammatory cytokines by directly scavenging oxygen free radicals,indirectly scavenging oxygen free radicals through increasing the body’s antioxidant enzyme activity,as well as blocking phosphatidylinositol 3-kinase(PI3K)-protein kinase B(Akt),extracellular signal-regulated kinase(ERK)-mitogen-activated protein kinase(MAPK)and Toll-like receptor(TLR)/MAPK/nuclear factorκB(NF-κB)signaling pathways,thereby producing antioxidant and anti-inflammatory effects and playing a protective role on the brain.In addition,magnolol and honokiol can counteract the damage of excitatory neurotransmitters to nerve cells by promoting the biosynthesis of the inhibitory neurotransmitter of Gamma-aminobutyric acid(GABA)and enhancing the receptor binding ability of GABA.In this paper,the protective effects of magnolol and honokiol on the brain injury and their mechanisms of actions are summarized,and the research progress is analyzed.

关 键 词：厚朴酚 和厚朴酚 脑保护作用 作用机制 

分 类 号：R961[医药卫生—药理学]