植物NLR免疫受体蛋白的结构生物学研究进展  

Structural insights into the plant NLR immune receptors

作　　者：李佳 陶小荣[1] LI Jia;TAO Xiaorong(Department of Plant Pathology,College of Plant Protection/Key Laboratory of Integrated Management of Crop Disease and Pests,Ministry of Education/The Key Laboratory of Plant Immunity,Nanjing Agricultural University,Nanjing 210095,China)

机构地区：[1]南京农业大学植物保护学院植物病理学系/教育部农作物生物灾害综合治理重点实验室/作物免疫学重点实验室,江苏南京210095

出　　处：《南京农业大学学报》2022年第5期929-937,共9页Journal of Nanjing Agricultural University

基　　金：国家自然科学基金重点项目(31630062)。

摘　　要：植物NLR(nucleotide binding leucine-rich repeat)蛋白是一类具有核苷酸结合域并富含亮氨酸重复序列的胞内免疫受体,通过识别进入细胞内的病原生物效应蛋白,激活植物免疫反应。近年来,植物NLR免疫受体蛋白的三维结构解析与生物学功能研究取得了诸多进展,从分子水平上揭示了植物NLR受体对病原生物效应蛋白的识别机制、受体多聚体化以及免疫信号激活机制,同时也为植物NLR免疫受体的人工设计和改造提供了重要的结构基础。本文综述了近十年植物NLR免疫受体蛋白的结构生物学研究进展,并探讨了未来该领域亟待回答的科学问题和面临的挑战。Nucleotide binding leucine-rich repeat(NLR)intracellular immune receptors in plants play critical roles in the detection of pathogen effectors and activation of the innate immune response.Tremendous progress in determining the three-dimensional structure and biological function of plant NLR has been made in recent years.These studies greatly improved our understanding of the pathogen recognition,receptor oligomerization and immune signal activation mechanism mediated by NLR,as well as provided a structural basis for the artificial design and modification of plant NLR.In this article,we reviewed the advances in the structural biology research of plant NLR immune receptor proteins in the past ten years,and discussed the scientific questions that need to be answered urgently and the challenges in the future.

关 键 词：NLR免疫受体 蛋白质三维结构 识别 激活 免疫受体设计与改造 

分 类 号：S432.1[农业科学—植物病理学]