酚妥拉明治疗极低体重儿喂养不耐受临床疗效分析  

Clinical Efficacy Analysis of Phentolamine in the Treatment of Feeding Intolerance in Very Low Birth Weight Infants

作　　者：李红亚[1] 王蓬春[1] 李斌[2] Li Hong-ya;Wang Peng-chun;Li Bin(Department of Neonatology,Baoding First Central Hospital,Baoding 071000,Hebei Province,China;Baoding Maternal and Child Health Hospital,Baoding 071000,Hebei Province,China)

机构地区：[1]保定市第一中心医院新生儿科,河北保定071000 [2]保定市妇幼保健院,河北保定071000

出　　处：《中外医药研究》2022年第4期24-26,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：保定市科技支撑计划项目(编号:17ZF212)。

摘　　要：目的:分析酚妥拉明治疗极低体重儿喂养不耐受(FI)的临床疗效。方法:选取2015年1月-2018年12月保定市第一中心医院新生儿科FI早产极低体重儿111例为观察对象,根据随机数表法分为观察组56例和对照组55例。两组均给予一般治疗,观察组在一般治疗基础上静脉泵入酚妥拉明,对照组在基本治疗基础上应用红霉素。比较两组治疗效果与矫正胎龄40周时体格指标增长情况。结果:观察组腹胀、胃潴留消失、达全肠道喂养、基础达标时间及住院时间短于对照组,差异有统计学意义(P<0.05);两组患儿矫正胎龄40周时各体格指标比较,差异无统计学意义(P>0.05)。结论:酚妥拉明治疗极低出生体重儿FI可有效缓解临床症状,缩短腹胀、胃潴留消失、基础达标、达全肠道喂养时间及住院时间,效果显著。Objective:To analyze the clinical efficacy of phentolamine in the treatment of feeding intolerance(FI)in very low birth weight infants.Methods:From January 2015 to December 2018,111 FI premature and very low birth weight infants in the Department of Neonatology,Baoding First Central Hospital were selected as the observation objects.According to the random number table method,they were divided into an observation group of 56 cases and a control group of 55 cases.Both groups were given general treatment,the observation group was given intravenous infusion of phentolamine on the basis of general treatment,and the control group was given erythromycin on the basis of basic treatment.The treatment effect and the growth of physique indexes at 40 weeks of corrected gestational age were compared between the two groups.Results:Abdominal distension,disappearance of gastric retention,complete enteral feeding,time to basic standard and hospital stay in the observation group were shorter than those in the control group,with statistically significant differences(P<0.05).There was no significant difference in the physical indicators between the two groups at the corrected gestational age of 40 weeks(P>0.05).Conclusion:Phentolamine in the treatment of very low birth weight infants with FI can effectively relieve clinical symptoms,shorten abdominal distension,disappearance of gastric retention,reach the basic standard,reach the time of total enteral feeding and hospitalization,and the effect is significant.

关 键 词：酚妥拉明 喂养不耐受 早产 极低出生体重儿 红霉素 

分 类 号：R72[医药卫生—儿科]