棕色脂肪组织内分泌功能的最新研究进展  

Recent Progress in Endocrine Function of Brown Adipose Tissue

作　　者：陈炜 刘佳琪[1,2,3,4] 刘禹熙 王新霞 CHEN Wei;LIU Jiaqi;LIU Yuxi;WANG Xinxia(College of Animal Sciences,Zhejiang University,Hangzhou 310058,China;Key Laboratory of Molecular Animal Nutrition(Zhejiang University),Ministry of Education,Hangzhou 310058,China;Key Laboratory of Animal Nutrition and Feed Science(Eastern of China),Ministry of Agriculture and Rural Affairs,Hangzhou 310058,China;Key Laboratory of Animal Feed and Nutrition of Zhejiang Province,Hangzhou 310058,China)

机构地区：[1]浙江大学动物科学学院,杭州310058 [2]浙江大学教育部“动物分子营养学”重点实验室,杭州310058 [3]农业农村部(华东)动物营养与饲料重点实验室,杭州310058 [4]浙江省饲料与动物营养重点实验室,杭州310058

出　　处：《中国细胞生物学学报》2022年第5期933-939,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金区域创新发展联合基金(批准号:U21A20249);浙江省重点项目(批准号:LZ22C170002)资助的课题。

摘　　要：棕色脂肪组织(brown adipocyte tissue,BAT)作为一个常规意义上的产热器官,与肥胖、Ⅱ型糖尿病、非酒精性脂肪肝等代谢疾病相关。目前研究发现,BAT除了参与能量代谢以外,也具有内分泌功能,可以通过分泌脂质因子(batokine)参与全身组织器官的调控。深入研究BAT对其他组织器官间的调控作用有助于为代谢疾病调控提供更有效的治疗策略。因此,该文对BAT的内分泌功能进行了综述,以期为靶向BAT介导的全身调控作用提供理论基础。As a conventional thermogenic organ,BAT (brown adipose tissue) is associated with obesity,type 2 diabetes,non-alcoholic fatty liver disease and other metabolic diseases.Current studies have found that BAT not only participates in energy metabolism,but also has endocrine function.BAT can regulate systemic tissues/organs by secreting lipid factors (batokine).Further studies on the regulatory effect of BAT on other tissues/organs will enable more effective therapeutic strategies for the treatment of metabolic diseases.Therefore,this review summarizes the endocrine function of BAT with the hope to provide a theoretical basis for targeting BAT-mediated systemic regulation.

关 键 词：棕色脂肪组织 内分泌 棕色脂肪因子 代谢 

分 类 号：Q493.5[生物学—生理学]