小RNA病毒与自噬的研究进展  

Research Progress of Picornavirus and Autophagy

作　　者：李娟 程安春 汪铭书 LI Juan;CHENG Anchun;WANG Mingshu(Avian Disease Research Center,College of Veterinary Medicine,Key Laboratory of Animal Diseases and Human Health of Sichuan Province,Institute of Preventive Veterinary Medicine,Sichuan Agricultural University,International Joint Center for Animal Disease Prevention and Control in Sichuan Province,Chengdu 611130,China)

机构地区：[1]四川农业大学动物医学院预防兽医研究所禽病防治研究中心动物疫病与人类健康四川省重点实验室四川省动物疫病防控国际联合中心,成都611130

出　　处：《中国细胞生物学学报》2022年第6期1109-1116,共8页Chinese Journal of Cell Biology

基　　金：财政部和农业农村部国家现代农业产业技术体系(批准号:CARS-42-17);国家农业产业技术体系四川兽药创新团队专项(批准号:SCCXTD-2020-18)资助的课题。

摘　　要：自噬是细胞的一种自我保护机制,是受损细胞器及大分子物质通过溶酶体降解再利用的过程。近年研究表明,小RNA病毒通过调控细胞自噬来促进自身复制。该文总结了小RNA病毒诱导细胞自噬的分子机制及病毒复制与自噬之间的关系,为小RNA病毒与自噬的研究提供参考。Autophagy is a self-protection mechanism of cells,which is the process of degrading and reusing damaged organelles and macromolecules through lysosomes.Recent studies have shown that picornaviruses promote their own replication by regulating autophagy.This paper summarizes the molecular mechanism of picornavirus inducing autophagy and the relationship between virus replication and autophagy,which provides a reference for the study of picornavirus and autophagy.

关 键 词：自噬 小RNA病毒 病毒复制 

分 类 号：Q939.4[生物学—微生物学]