不可忽视的性别差异——疼痛领域的探索  

Gender Differences that Cannot be Ignored——an Exploration of the Field of Pain

作　　者：鲁中芸 潘尉洲[2] 金华 LU Zhongyun;PAN Weizhou;JIN Hua(Medical School,Kunming University of Science and Technology,Kunming 650500,China;Department of Anesthesiology,the First People’s Hospital of Yunnan Province,Kunming 650032,China)

机构地区：[1]昆明理工大学医学院,昆明650500 [2]云南省第一人民医院麻醉科,昆明650032

出　　处：《中国细胞生物学学报》2022年第6期1219-1228,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号: 81860218);云南省科技厅–昆明医科大学应用基础研究联合专项(批准号: 2019FE001(-124)、202101AY070001-251)资助的课题。

摘　　要：性别差异是科学研究中广泛存在且被普遍忽视的问题,这一差异在医学研究领域尤为明显也十分重要。在现实生活中,几乎所有人都曾体验过或正在经受疼痛,所以相较于其他医学学科,疼痛领域存在的性别差异受到了更多关注。该文将从遗传学、神经免疫学、分子生物学、社会心理学等角度探讨疼痛的性别差异机制;并简述将性别视为生物学变量的重要性,以期强调性别差异在临床前及临床研究中的不可忽视性,为疼痛治疗及其相关基础研究的发展提供参考。Gender difference is a widespread and ignored problem in scientific research.This difference is particularly obvious and important in the field of medical research.In real life,almost everyone has experienced or is experiencing pain,so gender differences in pain have received more attention than in other medical disciplines.This article will discuss the gender differences in pain mechanisms from the perspectives of genetics,neuroimmunology,molecular biology,and social psychology;and describe the importance of gender in biological variables.It emphasizes the non-negligibility of gender differences in preclinical and clinical researches,and provides a basis for the development of pain treatment and related basic research.

关 键 词：疼痛 性别差异 SABV政策 

分 类 号：R402[医药卫生—临床医学]