前列腺素E2及其相关蛋白在难愈性创面修复中的作用研究  

Study on the role of prostaglandin E2 and its related proteins in healing refractory wounds

作　　者：迮侃[1,2] 蒯仂 卢怡 杨滢瑶 周蜜 祁菲[3] 陈思婷 李欣 李福伦 李斌[2,4] ZE Kan;KUAI Le;LU Yi;YANG Yingyao;ZHOU Mi;QI Fei;CHEN Siting;LI Xin;LI Fulun;LI Bin(Department of Dermatology,Yueyang Hospital of Integrative Medicine Afliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200434,China;Institute of Dermatology,Shanghai Institute of Traditional Chinese Medicine,Shanghai 200434,China;Department of Vascular Medicine,Shanghai Hospital of Integrative Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200082,China;Shanghai Hospial of Dermatology,Shanghai 200443,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院皮肤科,上海200434 [2]上海市中医药研究院皮肤病研究所,上海200434 [3]上海中医药大学附属中西医结合医院脉管科,上海200082 [4]上海市皮肤病医院,上海200443

出　　处：《世界临床药物》2022年第7期952-956,共5页World Clinical Drug

基　　金：国家自然科学基金项目(81704085,81904214);国家重点研发计划中医药现代化研究重点专项(2018YFC1705305);上海市科委优秀学术带头人计划(20XD1423600);上海市教育委员会“曙光计划”(17SG41);上海市临床重点专科建设项目——中医皮肤病科(shslczdzk05001);上海市进一步加快中医药事业发展三年行动计划[ZY(2018-2020)-FWTX-4010]。

摘　　要：前列腺素(prostaglandin,PG)E具有扩张血管、舒缓平滑肌的作用,已在消化道黏膜创面修复中发挥重要作用。环氧合酶是PGE的主要合成酶,而PG转运蛋白和15-羟基PG脱氢酶是其主要的代谢蛋白。该文通过综述PGE、环氧合酶、PG转运蛋白和15-羟基PG脱氢酶在创面修复中的作用,以探讨PGE为核心的创面修复特点,为未来选择较好的促进创面修复的药物靶点提供一些思路和手段。Prostaglandin Ehas the function of dilating blood vessels and soothing smooth muscles,and has been found to play an important role in the repair of gastrointestinal mucosal wounds.Cyclooxygenase is the main synthetase of prostaglandin(PG)E,and prostaglandin transporter and 15-hydroxyprostaglandin dehydrogenase are the main metabolic proteins.In this paper,the role of PGE,cyclooxygenase,prostaglandin transporter and 15-hydroxyprostaglandin dehydrogenase in wound repair were reviewed to explore the characteristics of wound repair with PGEas the core,so as to provide some ideas and means for selecting better drug targets to promote wound repair in the future.

关 键 词：前列腺素E2 环氧合酶 前列腺素转运蛋白 15-羟基前列腺素脱氢酶 创面修复 

分 类 号：R632.1[医药卫生—外科学] R587.2[医药卫生—临床医学]