帕瑞昔布钠超前镇痛对肺结节定位穿刺术后镇痛效果的影响  

Impact of preemptive analgesia with parecoxib sodium on the analgesic effect after pulmonary nodule positioning puncture

作　　者：陆志斌[1] 陆龙 江璠 林毓秋 房颖[1] 占根生 周存荣[1] LU Zhi-bin;LU Long;JIANG Fan;LIN Yu-qiu;FANG Ying;ZHAN Gen-sheng;ZHOU Cun-rong(Department of Cardiothoracic Surgery,Pukou Branch Hospital of Jiangsu Province Hospital,Nanjing,Jiangsu 211800,China;Department of Medical Imaging,Pukou Branch Hospital of Jiangsu Province Hospital,Nanjing,Jiangsu 211800,China)

机构地区：[1]江苏省人民医院浦口分院心胸外科,江苏南京211800 [2]江苏省人民医院浦口分院影像科,江苏南京211800

出　　处：《临床肺科杂志》2022年第10期1523-1526,共4页Journal of Clinical Pulmonary Medicine

基　　金：南京市浦口区科技发展项目(NO.S2020-22)。

摘　　要：目的探究肺结节定位穿刺术患者,术前加用帕瑞昔布钠的镇痛效果,评价其对首次定位的准确度及术后并发症的影响。方法以随机对照双盲法行临床试验,选取2020年10月~2021年6月本院收治的接受肺结节定位穿刺术患者142例,随机分为对照组68例、观察组74例,对照组于常规医疗基础上,术前30 min上肢外周静脉注射0.9%氯化钠注射液2 mL,观察组术前30 min上肢外周静脉注射40mg帕瑞昔布钠,分析2组术后疼痛评分、术后穿刺定位的准确度及气胸与血胸、严重不良反应情况。结果观察组患者术后5 min、15 min、30 min、60 min疼痛评分较对照组患者的相比明显较低(P<0.05)。观察组患者术后穿刺定位准确度较高,且气胸、血胸较少发生,较对照组相比差异显著(P<0.05)。观察组患者术后的严重不良事件发生率较低,且显著低于对照组患者(P<0.05)。结论肺结节定位穿刺术患者术前加用帕瑞昔布钠的镇痛效果较好,提高定位准确度,意义重大。Objective To explore the analgesic effect of parecoxib sodium in patients undergoing pulmonary nodule localization and puncture before operation,and to evaluate its effect on the accuracy of first localization and postoperative complications.Methods A randomized controlled double-blind clinical trial was conducted.142 patients who underwent pulmonary nodule localization puncture in our hospital from October 2020 to June 2021 were selected and randomly divided into the control group(n=68)and the observation group(n=74).In the control group,2 mL of 0.9%sodium chloride injection was injected into the upper limbs 30 minutes before the operation on the basis of routine medical treatment,and the observation group was injected with 40mg parecoxib sodium 30 minutes before the operation.The postoperative pain score,the accuracy of postoperative puncture positioning,pneumothorax and hemothorax,and serious adverse reactions were analyzed between the two groups.Results The pain scores of patients in the observation group at 5 min,15 min,30 min,and 60 min after operation were significantly lower than those in the control group(P<0.05).Compared with the control group,the postoperative puncture positioning accuracy was higher in the observation group,and the occurrence of pneumothorax and hemothorax was less,and the differences were statistically significant(P<0.05).The incidence of postoperative serious adverse events in the observation group was significantly lower than that in the control group(P<0.05).Conclusion For patients with pulmonary nodule positioning puncture,the application of parecoxib sodium before operation has a better analgesic effect.It can improve positioning accuracy,and reduce postoperative complications,which is of great significance.

关 键 词：肺结节定位穿刺术 帕瑞昔布钠 镇痛 

分 类 号：R614[医药卫生—麻醉学]