新安医籍中含药对“羌活-独活”治疗痹病方剂的探析  

Literature Research on “Qianghuo-Duhuo” Prescriptions for Bi Disease in Xin’an Medical Books

作　　者：许霞[1] 孙广瀚 李笑男 刘静[1] 赵黎[1] 刘莹[1] XU Xia;SUN Guanghan;LI Xiaonan;LIU Jing;ZHAO Li;LIU Ying(Department of Prescriptions,Anhui University of Traditional Chinese Medicine,Hefei 230012,China)

机构地区：[1]安徽中医药大学中医学院方药系,安徽合肥230012

出　　处：《湖北民族大学学报（医学版）》2022年第3期39-43,共5页Journal of Hubei Minzu University(Medical Edition)

基　　金：安徽省哲学社会科学规划项目研究成果(AHSKY2019D070)。

摘　　要：目的 对新安医籍中运用药对“羌活-独活”治疗痹病的方剂进行文献整理和数据分析,为临床应用提供参考。方法 在新安医学痹病文献数据库筛选新安医家治疗痹病中含药对“羌活-独活”的方剂,并进行文献整理和数据分析。结果 经去除重复药方后共计60方,190味药,其中羌活胜湿汤及蠲痹汤为最常出现的方剂。通过关联规则分析,从使用频率≥10的27味中药中挖掘出羌活、独活常与防风或姜黄或甘草或炙甘草组成角药,其中羌活、独活、防风角药常与附子、麻黄、茯苓、人参、生姜、白芍、泽泻、猪苓、没药、陈皮、白术、姜黄、甘草、炙甘草配伍,羌活、独活、甘草角药常与海风藤、麻黄、附子、茯苓、人参配伍,羌活、独活、姜黄角药常与附子、茯苓、白芍、泽泻、陈皮、猪苓、芍药配伍,羌活、独活、炙甘草角药常与附子、麻黄、茯苓、人参、生姜、白芍、泽泻、猪苓、没药、陈皮、白术、姜黄配伍,羌活、独活、猪苓角药常与人参配伍,支持度均≥16%,置信度均≥80%,提升≥1。发现潜在药物组合,并通过复杂网络图发现支持度>50的方剂中核心药物为羌活、独活、海风藤、木瓜、麻黄、附子。结论 羌活、独活在新安医学治疗痹病方剂中常常出现,并和其他药物组成鼎药,能在临床进一步使用。Objective To conduct a literature research on the prescription of “Qianghuo-Duhuo” for Bi disease in Xin’an medical books, so as to provide reference for clinical application.Methods The prescriptions of “Qianghuo-Duhuo” for Bi disease in the Xin’an Medical Arthralgia Literature Database were screened, and the mechanism of action was explored using network pharmacology and molecular docking.Results A total of 60 prescriptions involving 190 medicines were removed after the repeated prescriptions were removed.Among them, Qianghuo Shengshi Decoction and Juanbi Decoction were the most common prescriptions.Through the analysis of association rules, it was discovered that Qianghuo, Duhuochang and Fangfeng or turmeric or licorice or licorice were used to form horn medicines from the 27 traditional Chinese medicines with a frequency of ≥10.Qianghuo, Duhuo and Fangfengjiao medicines are often combined with aconite, ephedra, poria, ginseng, ginger, white peony, Alisma, Polyporus, myrrh, tangerine peel, Atractylodes, turmeric, licorice, and licorice.Qianghuo, Duhuo and Licorice horn medicines are often combined with Haifengteng, Mahuang, Fuzi, Poria and Ginseng.Qianghuo, Duhuo, and turmeric horn medicines are often combined with Aconite, Poria, Baishao, Alisma, tangerine peel, Polyporus, and Shaoyao.Qianghuo, Duhuo, Zhigancaojiao medicines are often combined with aconite, ephedra, tuckahoe, ginseng, ginger, white peony, Alisma, Polyporus, myrrh, tangerine peel, Atractylodes, and turmeric.Qianghuo, Duhuo and Polyporus horn medicines are often combined with ginseng(Support degree≥ 16%,support confidence degree≥ 80%,improvement ≥ 1).Potential drug combinations was found, and through complex network diagrams, it was found that the core drugs in the formula with a support degree>50 are Qianghuo, Duhuo, Haifengteng, papaya, ephedra, and aconite.Conclusion Qiang Huo and Du Huo often appear in Xin’an Medicine’s prescriptions for Bi disease, and together with other drugs to form Ding Medicine, which can be fu

关 键 词：新安医籍 新安医学痹病文献数据库 羌活 独活 

分 类 号：R289.5[医药卫生—方剂学]